ORGANIZATION AND EXPRESSION OF SMALL SUBUNIT RIBOSOMAL-RNA GENES ENCODED BY A 35-KILOBASE CIRCULAR DNA IN PLASMODIUM-FALCIPARUM

被引：62

作者：

GARDNER, MJ

FEAGIN, JE

MOORE, DJ

SPENCER, DF

GRAY, MW

WILLIAMSON, DH

WILSON, RJM

机构：

[1] NATL INST MED RES,DIV PARASITOL,LONDON NW7 1AA,ENGLAND

[2] NATL INST MED RES,CELL PROPAGAT LAB,LONDON NW7 1AA,ENGLAND

[3] SEATTLE BIOMED RES INST,SEATTLE,WA

[4] DALHOUSIE UNIV,DEPT BIOCHEM,HALIFAX B3H 4H2,NS,CANADA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1991年 / 48卷 / 01期

基金：

英国医学研究理事会;

关键词：

PLASMODIUM-FALCIPARUM; ORGANELLAR RIBOSOMAL RNA; CIRCULAR DNA;

D O I：

10.1016/0166-6851(91)90166-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A restriction map of the 35-kb circular DNA molecule of Plasmodium falciparum showed that a region of about 6 kb, encoding both a large and a small subunit ribosomal RNA gene, has been duplicated in inverted orientation. The complete sequence of one small subunit rRNA gene is presented as well as an analysis of transcripts from erythrocytic stage parasites. Comparative sequence analysis of the rRNA gene and the proposed secondary structure of the rRNA suggest that it is of organellar origin. Intriguingly, while some characteristics of the small subunit rRNA gene are similar to mitochondrial sequences, others are more like those of plastids. The origin of the circular DNA molecule and evolutionary implications of its genetic content are discussed.

引用

页码：77 / 88

页数：12

共 35 条

[1] SEQUENCE IDENTIFICATION OF CYTOCHROME-B IN PLASMODIUM-GALLINACEUM
ALDRITT, SM
JOSEPH, JT
WIRTH, DF
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (09) : 3614 - 3620
[2] THE EVOLUTIONARY RELATIONSHIPS AMONG KNOWN LIFE FORMS
CEDERGREN, R
GRAY, MW
ABEL, Y
SANKOFF, D
[J]. JOURNAL OF MOLECULAR EVOLUTION, 1988, 28 (1-2) : 98 - 112
[3] CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[4] COMPILATION OF SMALL RIBOSOMAL-SUBUNIT RNA SEQUENCES
DAMS, E
HENDRIKS, L
VANDEPEER, Y
NEEFS, JM
SMITS, G
VANDENBEMPT, I
DEWACHTER, R
[J]. NUCLEIC ACIDS RESEARCH, 1988, 16 : R87 - R173
[5] THE MITOCHONDRION OF PLASMODIUM-FALCIPARUM VISUALIZED BY RHODAMINE-123 FLUORESCENCE
DIVO, AA
GEARY, TG
JENSEN, JB
GINSBURG, H
[J]. JOURNAL OF PROTOZOOLOGY, 1985, 32 (03): : 442 - 446
[6] FURTHER-STUDIES AND ELECTRON-MICROSCOPIC CHARACTERIZATION OF PLASMODIUM-BERGHEI DNA
DORE, E
FRONTALI, C
FORTE, T
FRATARCANGELI, S
[J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1983, 8 (04) : 339 - 352
[7] DEVELOPMENTALLY REGULATED ADDITION OF NUCLEOTIDES WITHIN APOCYTOCHROME-B TRANSCRIPTS IN TRYPANOSOMA-BRUCEI
FEAGIN, JE
JASMER, DP
STUART, K
[J]. CELL, 1987, 49 (03) : 337 - 345
[8] APOCYTOCHROME-B AND OTHER MITOCHONDRIAL-DNA SEQUENCES ARE DIFFERENTIALLY EXPRESSED DURING THE LIFE-CYCLE OF TRYPANOSOMA-BRUCEI
FEAGIN, JE
JASMER, DP
STUART, K
[J]. NUCLEIC ACIDS RESEARCH, 1985, 13 (12) : 4577 - 4596
[9] CREATION OF AUG INITIATION CODONS BY ADDITION OF URIDINES WITHIN CYTOCHROME-B TRANSCRIPTS OF KINETOPLASTIDS
FEAGIN, JE
SHAW, JM
SIMPSON, L
STUART, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (02) : 539 - 543
[10] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY
FEINBERG, AP
VOGELSTEIN, B
[J]. ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) : 6 - 13

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