ORGANIZATION AND EXPRESSION OF SMALL SUBUNIT RIBOSOMAL-RNA GENES ENCODED BY A 35-KILOBASE CIRCULAR DNA IN PLASMODIUM-FALCIPARUM

被引：62

作者：

GARDNER, MJ

FEAGIN, JE

MOORE, DJ

SPENCER, DF

GRAY, MW

WILLIAMSON, DH

WILSON, RJM

机构：

[1] NATL INST MED RES,DIV PARASITOL,LONDON NW7 1AA,ENGLAND

[2] NATL INST MED RES,CELL PROPAGAT LAB,LONDON NW7 1AA,ENGLAND

[3] SEATTLE BIOMED RES INST,SEATTLE,WA

[4] DALHOUSIE UNIV,DEPT BIOCHEM,HALIFAX B3H 4H2,NS,CANADA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1991年 / 48卷 / 01期

基金：

英国医学研究理事会;

关键词：

PLASMODIUM-FALCIPARUM; ORGANELLAR RIBOSOMAL RNA; CIRCULAR DNA;

D O I：

10.1016/0166-6851(91)90166-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A restriction map of the 35-kb circular DNA molecule of Plasmodium falciparum showed that a region of about 6 kb, encoding both a large and a small subunit ribosomal RNA gene, has been duplicated in inverted orientation. The complete sequence of one small subunit rRNA gene is presented as well as an analysis of transcripts from erythrocytic stage parasites. Comparative sequence analysis of the rRNA gene and the proposed secondary structure of the rRNA suggest that it is of organellar origin. Intriguingly, while some characteristics of the small subunit rRNA gene are similar to mitochondrial sequences, others are more like those of plastids. The origin of the circular DNA molecule and evolutionary implications of its genetic content are discussed.

引用

页码：77 / 88

页数：12

共 35 条

[21] MITOCHONDRIA AS THE SITE OF ACTION OF TETRACYCLINE ON PLASMODIUM-FALCIPARUM
KIATFUENGFOO, R
SUTHIPHONGCHAI, T
PRAPUNWATTANA, P
YUTHAVONG, Y
[J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 34 (02) : 109 - 115
[22] CIRCULAR MITOCHONDRIAL-DNA FROM AVIAN MALARIAL PARASITE PLASMODIUM-LOPHURAE
KILEJIAN, A
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 390 (03) : 276 - 284
[23] INTERACTION OF ANTIBIOTICS WITH FUNCTIONAL SITES IN 16S RIBOSOMAL-RNA
MOAZED, D
NOLLER, HF
[J]. NATURE, 1987, 327 (6121) : 389 - 394
[24] PALMER JD, 1985, ANNU REV GENET, V19, P325, DOI 10.1146/annurev.ge.19.120185.001545
[25] Sambrook J., 1989, MOL CLONING LAB MANU
[26] DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS
SANGER, F
NICKLEN, S
COULSON, AR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) : 5463 - 5467
[27] BIOCHEMISTRY OF PLASMODIUM (MALARIAL PARASITES)
SHERMAN, IW
[J]. MICROBIOLOGICAL REVIEWS, 1979, 43 (04) : 453 - 495
[28] APPLICATION OF THE SERIAL SECTIONING AND TRIDIMENSIONAL RECONSTRUCTION TECHNIQUES TO THE MORPHOLOGICAL-STUDY OF THE PLASMODIUM-FALCIPARUM MITOCHONDRION
SLOMIANNY, C
PRENSIER, G
[J]. JOURNAL OF PARASITOLOGY, 1986, 72 (04) : 595 - 598
[29] CULTIVATION OF MALARIAL PARASITES
TRAGER, W
JENSON, JB
[J]. NATURE, 1978, 273 (5664) : 621 - 622
[30] TUNGPRADABKUL S, 1985, APPLICATION GENETIC, P51

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