TOXICITY OF PULPISPAD USING 4 DIFFERENT CELL-TYPES

被引：18

作者：

PISSIOTIS, E ^{[1
]}

SPANGBERG, LSW ^{[1
]}

机构：

[1] UNIV CONNECTICUT,CTR HLTH,SCH DENT MED,DEPT RESTORAT DENT & ENDODONTOL,FARMINGTON,CT 06030

来源：

INTERNATIONAL ENDODONTIC JOURNAL | 1991年 / 24卷 / 05期

关键词：

D O I：

10.1111/j.1365-2591.1991.tb01150.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The cytotoxic effect of a zinc oxide-eugenol-based paste (Pulpispad) was evaluated in vitro after setting for 1 day and 1 week. Target cells were L929 cells, gingival, periodontal ligament and pulpal fibroblasts. The material was incubated with the cells for 4 and 24 hours, and its toxicity was evaluated with the Cr-51-release method. Pulpispad was highly cytotoxic to all cell lines even after setting for 1 week. The use of Pulpispad is not recommended for future clinical application. The various responses among the four cell lines indicated that diploid cell lines can, under certain circumstances, be less sensitive than aneuploid cell lines. It is therefore suggested that in the evaluation of biomaterials the choice of cell lines should be carefully considered, as they can display varying sensitivities.

引用

页码：249 / 257

页数：9

共 45 条

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