3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) MONOPHOSPHATE - AN INHIBITOR OF EXONUCLEOLYTIC REPAIR OF AZT-TERMINATED DNA

被引:45
作者
HARRINGTON, JA
REARDON, JE
SPECTOR, T
机构
关键词
D O I
10.1128/AAC.37.4.918
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
A 3'-exonuclease(s) that excised 3'-azido-3'-deoxythymidine (AZT) monophosphate (AZTMP) from the 3' terminus of DNA was partially purified from two human cell lines. AZTMP inhibited the hydrolysis of AZTMP-terminated single-stranded and double-stranded DNA substrates. Thus, high levels of AZTMP might inhibit the exonuclease and trigger the toxicity of AZT by impairing the repair of AZTMP-terminated DNA.
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页码:918 / 920
页数:3
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