3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) MONOPHOSPHATE - AN INHIBITOR OF EXONUCLEOLYTIC REPAIR OF AZT-TERMINATED DNA

被引：45

作者：

HARRINGTON, JA

REARDON, JE

SPECTOR, T

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 04期

关键词：

D O I：

10.1128/AAC.37.4.918

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A 3'-exonuclease(s) that excised 3'-azido-3'-deoxythymidine (AZT) monophosphate (AZTMP) from the 3' terminus of DNA was partially purified from two human cell lines. AZTMP inhibited the hydrolysis of AZTMP-terminated single-stranded and double-stranded DNA substrates. Thus, high levels of AZTMP might inhibit the exonuclease and trigger the toxicity of AZT by impairing the repair of AZTMP-terminated DNA.

引用

页码：918 / 920

页数：3

共 24 条

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