TIME-DEPENDENT EFFECTS OF PCPA ON SOCIAL AGGRESSION IN CHICKS

被引:21
作者
BUCHANAN, CP [1 ]
SHRIER, EM [1 ]
HILL, WL [1 ]
机构
[1] LAFAYETTE COLL, DEPT PSYCHOL, EASTON, PA 18042 USA
关键词
AGGRESSION; DOMESTIC CHICKS; P-CHLOROPHENYLALANINE (PCPA); SEROTONIN;
D O I
10.1016/0091-3057(94)90059-0
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
We investigated the effects of para-chlorophenylalanine (PCPA), a serotonin (5-HT) antagonist, on social aggression and brain neurochemistry in young domestic chickens (Gallus domesticus). In Experiment 1, the effects of four different doses of PCPA (0, 100, 200, and 400 mg/kg) were examined for 3 days after injection. Immediately after PCPA injection, aggressive pecking was low and then increased over the 3-day test period. PCPA significantly decreased 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), and 5-HT turnover. In addition, the frequency of aggression was negatively correlated with levels of 5-HIAA. In Experiment 2, the time-dependent effects of a single 400-mg/kg dose of PCPA were examined for 5 and 7 days after drug exposure. PCPA-treated chicks observed for 5 days after injection had significantly greater frequencies of aggression 4 days following drug exposure and significantly reduced 5-HT levels when measured on the next day. Similarly, chicks observed for 7 days exibited significantly elevated aggression 5 days after injection, after which their pecking decreased to control levels on days 6 and 7. Coinciding with this behavioral pattern, 5-HT levels from these PCPA-treated chicks when assessed 7 days after drug exposure were the same as those for control birds. We concluded that PCPA increased social aggression in birds, an effect that diminished as brain 5-HT levels recovered over a 1-week period.
引用
收藏
页码:483 / 488
页数:6
相关论文
共 37 条
[31]  
SMITH SE, 1986, AGGRESSIVE BEHAV, V12, P393, DOI 10.1002/1098-2337(1986)12:6<393::AID-AB2480120602>3.0.CO
[32]  
2-L
[33]   FEEDING-BEHAVIOR OF CHICKS UNDER 3 LIGHTING REGIMENS [J].
SQUIBB, RL ;
COLLIER, GH .
POULTRY SCIENCE, 1979, 58 (03) :641-645
[34]   EFFECTS OF P-CHLOROPHENYLALANINE A SEROTONIN DEPLETOR ON AVOIDANCE ACQUISITION PAIN SENSITIVITY AND RELATED BEHAVIOR IN RAT [J].
TENEN, SS .
PSYCHOPHARMACOLOGIA, 1967, 10 (03) :204-204
[35]   TIME-COURSES OF P-CPA-INDUCED DEPLETION OF BRAIN-SEROTONIN AND MURICIDAL AGGRESSION IN THE RAT [J].
VALZELLI, L ;
BERNASCONI, S ;
DALESSANDRO, M .
PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1983, 15 (04) :387-395
[36]   PARACHLOROPHENYLALANINE-INDUCED SEROTONIN DEPLETION INCREASES OFFENSIVE BUT NOT DEFENSIVE AGGRESSION IN MALE-RATS [J].
VERGNES, M ;
DEPAULIS, A ;
BOEHRER, A .
PHYSIOLOGY & BEHAVIOR, 1986, 36 (04) :653-658
[37]   EFFECTS OF MONOAMINERGIC AGONISTS ON ALCOHOL-INDUCED INCREASES IN MOUSE AGGRESSION [J].
WAGNER, GC ;
FISHER, H ;
POLE, N ;
BORVE, T ;
JOHNSON, SK .
JOURNAL OF STUDIES ON ALCOHOL, 1993, :185-191