DEPLETION OF CALCITONIN GENE-RELATED PEPTIDE IN PERIVASCULAR NERVES DURING ACUTE PHASE OF POSTHEMORRHAGIC VASOSPASM IN THE RABBIT

被引：18

作者：

ARIENTA, C ^{[1
]}

BALBI, S ^{[1
]}

CAROLI, M ^{[1
]}

FUMAGALLI, G ^{[1
]}

机构：

[1] UNIV MILAN,DEPT PHARMACOL,I-20100 MILAN,ITALY

来源：

BRAIN RESEARCH BULLETIN | 1991年 / 27卷 / 05期

关键词：

CEREBRAL VASOSPASM; SUBARACHNOID HEMORRHAGE; CALCITONIN GENE-RELATED PEPTIDE; NEUROPEPTIDES;

D O I：

10.1016/0361-9230(91)90034-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The behaviour of various neuropeptides during early and late vasospasm following experimental subarachnoid hemorrhage has been investigated by several authors. Recently, a reduction of the content of vasodilatory neuropeptides (vasodilatory intestinal peptide, substance P and calcitonin gene-related peptide) has been demonstrated in the perivascular nerves of cerebral arteries after few days from induction of experimental subarachnoid hemorrhage. In the present immunohistochemical study, the authors investigated secretion and expression of CGRP a few minutes after injection of autologous blood into the cisterna magna of the rabbit. The authors propose that the marked decrease of calcitonin gene-related peptide immunoreactivity in the perivascular nerves, observed after experimental subarachnoid hemorrhage, is due to compensatory secretion of the peptide.

引用

页码：605 / 609

页数：5

共 32 条

[11] CALCITONIN GENE-RELATED PEPTIDE (CGRP) IS A POTENT NON-ENDOTHELIUM-DEPENDENT INHIBITOR OF CORONARY VASOMOTOR TONE [J].