RETINOIDS INHIBIT MAMMALIAN GLUTATHIONE TRANSFERASES

被引：16

作者：

KULKARNI, AA ^{[1
]}

KULKARNI, AP ^{[1
]}

机构：

[1] UNIV S FLORIDA,COLL PUBL HLTH,DEPT ENVIRONM & OCCUPAT HLTH,FLORIDA TOXICOL RES CTR,TAMPA,FL 33612

来源：

CANCER LETTERS | 1995年 / 91卷 / 02期

关键词：

GLUTATHIONE TRANSFERASES; INHIBITION; RETINOIDS; CANCER TREATMENT;

D O I：

10.1016/0304-3835(95)03749-M

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Affinity-purified cytosolic glutathione transferases from adult female rat liver, adult human liver and human term placenta were used. Of the 8 retinoids tested, all-trans retinoic acid was found to be the most potent inhibitor of placental glutathione transferase. The inhibition was non-competitive and exhibited K-i values of 20 and 41 mu M for all-trans retinoic acid in the presence of varying concentrations of 1-chloro-2,4-dinitrobenzene and glutathione, respectively. Micromolar all-trans retinoic acid also caused significant (30-90%) inhibition of rat and human liver glutathione transferases. Taken together, the data suggest that inhibition of glutathione transferase(s) may represent yet another mechanism of retinoid action.

引用

页码：185 / 189

页数：5

共 25 条

[1] THE EFFECTS OF RETINOIC ACID ON THE INVITRO AND INVIVO GROWTH OF NEUROBLASTOMA-CELLS [J].