GENETIC TOXICOLOGY TESTING OF 41 INDUSTRIAL-CHEMICALS

被引:96
作者
DEAN, BJ
BROOKS, TM
HODSONWALKER, G
HUTSON, DH
机构
来源
MUTATION RESEARCH | 1985年 / 153卷 / 1-2期
关键词
D O I
10.1016/0165-1110(85)90005-3
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Compounds or mixtures (41) of diverse structure and application were tested for genotoxic activity. The materials were tested in bacterial mutation assays, in Saccharomyces cerevisiae JD1 for mitotic gene conversion and in a cultured rat-liver cell line for structural chromosome damage. Eleven compounds were bacterial mutagens, 4 induced mitotic gene conversion in yeast and 5 were positive in the chromosome assay. Of the materials, 5 were positive in bacteria only and 2 compounds induced chromosome damage in cultured cells in the absence of mutation in bacteria or gene conversion in yeast. The materials were tested over a 5-yr period and the performance and evolution of the 3 assays during this time is evaluated. The results are considered in relation to the structure of the chemicals and the genotoxicity of related compounds.
引用
收藏
页码:57 / 77
页数:21
相关论文
共 51 条
[11]   THE PROTECTIVE ACTION OF GLUTATHIONE ON THE MICROBIAL MUTAGENICITY OF THE Z-ISOMER AND E-ISOMER OF 1,3-DICHLOROPROPENE [J].
CREEDY, CL ;
BROOKS, TM ;
DEAN, BJ ;
HUTSON, DH ;
WRIGHT, AS .
CHEMICO-BIOLOGICAL INTERACTIONS, 1984, 50 (01) :39-48
[12]  
DAVIES PJ, 1975, MUTAT RES, V29, P301, DOI 10.1016/0165-1218(75)90092-0
[13]   INVITRO CHROMOSOME ASSAY USING CULTURED RAT-LIVER CELLS [J].
DEAN, BJ ;
HODSONWALKER, G .
MUTATION RESEARCH, 1979, 64 (05) :329-337
[14]   GENETIC TOXICOLOGY OF BENZENE, TOLUENE, XYLENES AND PHENOLS [J].
DEAN, BJ .
MUTATION RESEARCH, 1977, 47 (02) :75-97
[15]   MUTAGENIC EFFECTS OF ORGANOPHOSPHORUS PESTICIDES ON MICROORGANISMS [J].
DEAN, BJ .
ARCHIV FUR TOXIKOLOGIE, 1972, 30 (01) :67-74
[16]   PARADOXICAL IN VITRO EFFECT OF A RADIOPROTECTIVE AGENT ON MITOSIS AND CHROMOSOMES [J].
DELREZ, M ;
FIRKET, H .
BIOCHEMICAL PHARMACOLOGY, 1968, 17 (09) :1893-&
[17]   GENETIC TOXICOLOGY OF XYLENES [J].
DONNER, M ;
MAKIPAAKKANEN, J ;
NORPPA, H ;
SORSA, M ;
VAINIO, H .
MUTATION RESEARCH, 1980, 74 (03) :171-172
[18]   EVALUATION OF A DNA POLYMERASE-DEFICIENT MUTANT OF ESCHERICHIA-COLI FOR RAPID DETECTION OF CARCINOGENS [J].
FLUCK, ER ;
POIRIER, LA ;
RUELIUS, HW .
CHEMICO-BIOLOGICAL INTERACTIONS, 1976, 15 (03) :219-231
[19]  
GARNER RC, 1977, MUTAT RES, V44, P9
[20]   MUTAGENICITY OF PARA-NITROSOPHENOL [J].
GILBERT, P ;
RONDELET, J ;
PONCELET, F ;
MERCIER, M .
FOOD AND COSMETICS TOXICOLOGY, 1980, 18 (05) :523-525