DNA PLOIDY OF PRIMARY BREAST-CANCER AND LOCAL RECURRENCE AFTER BREAST-CONSERVING THERAPY

被引:21
作者
BEERMAN, H
BONSING, BA
VANDEVIJVER, MJ
HERMANS, J
KLUIN, PM
CASPERS, RJ
VANDEVELDE, CJH
CORNELISSE, CJ
机构
[1] LEIDEN UNIV HOSP,2333 AA LEIDEN,NETHERLANDS
[2] LEIDEN UNIV,DEPT PATHOL,LEIDEN,NETHERLANDS
[3] LEIDEN UNIV,DEPT MED STAT,LEIDEN,NETHERLANDS
[4] LEIDEN UNIV,DEPT RADIOTHERAPY,LEIDEN,NETHERLANDS
[5] LEIDEN UNIV,FAC MED,DEPT SURG,LEIDEN,NETHERLANDS
关键词
D O I
10.1038/bjc.1991.257
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The value of DNA-flow cytometry and clinico-pathological prognostic factors for the prediction of local recurrences after breast-conserving therapy (BCT) were evaluated in a retrospective study. Thirty-one patients with a local recurrence were compared with 31 matched patients without a local recurrence. Morphology and DNA-indices of the local recurrences and their corresponding primary tumours were compared. Ductal carcinoma in situ was present significantly more often in the group with a primary recurring tumour, than in the matched group (P < 0.001), and the same holds for lobular carcinoma (n = 5). Half of the tumours that recurred had macroscopically positive surgical margins compared to about one-fourth of the matched group. Fifty-six per cent of the DNA-aneuploid stemlines in cases with local recurrence were present in the corresponding primary tumour as well (confidence limits 45%-75%), an indication that the majority of local recurrences are true recurrences and not independently developed tumours. The lack of similarity of DNA stemlines between some primary DNA-aneuploid tumours and their local recurrence indicates that these tumours had developed independently. The percentage of DNA-aneuploid cases in the group with local recurrence (89%) did not differ significantly from that in the matched group (70%). However, the findings suggest a selective recurrence of DNA-diploid stemlines. This might indicate increased resistance of DNA-diploid tumour cells to radiotherapy as compared with the resistance level in DNA-aneuploid cells.
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页码:139 / 143
页数:5
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