ROGUE LYMPHOCYTES AMONG UKRAINIANS NOT EXPOSED TO RADIOACTIVE FALLOUT FROM THE CHERNOBYL ACCIDENT - THE POSSIBLE ROLE OF THIS PHENOMENON IN ONCOGENESIS, TERATOGENESIS, AND MUTAGENESIS

被引：40

作者：

NEEL, JV ^{[1
]}

AWA, AA ^{[1
]}

KODAMA, Y ^{[1
]}

NAKANO, M ^{[1
]}

MABUCHI, K ^{[1
]}

机构：

[1] RADIAT EFFECTS RES FDN,MINAMI KU,HIROSHIMA 732,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1992年 / 89卷 / 15期

关键词：

D O I：

10.1073/pnas.89.15.6973

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cultured lymphocytes exhibiting extreme cytogenetic damage (rogue cells) were observed in preparations from 8 of 24 individuals sampled in Krasilovka, a Ukrainian village receiving little or no increased radiation after the Chernobyl disaster, but were not observed in an additional 24 persons from two Russian towns in the more contaminated area. This observation cements the worldwide occurrence of these cells. The present data plus a review of the literature establish that rogue cells appear in brief bursts simultaneously in certain individuals of discrete populations. We suggest that the pattern is consistent with the action of a viral trigger that acts directly or indirectly-the latter possibly through the activation of latent chromosomal retroposons. If this phenomenon occurs in other tissues, it may have important implications for oncogenesis, teratogenesis, mutagenesis, and evolution.

引用

页码：6973 / 6977

页数：5

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