IDENTIFICATION OF A GRAFT-VERSUS-HOST DISEASE-ASSOCIATED HUMAN MINOR HISTOCOMPATIBILITY ANTIGEN

被引：327

作者：

DENHAAN, JMM

SHERMAN, NE

BLOKLAND, E

HUCZKO, E

KONING, F

DRIJFHOUT, JW

SKIPPER, J

SHABANOWITZ, J

HUNT, DF

ENGELHARD, VH

GOULMY, E

机构：

[1] UNIV LEIDEN HOSP, DEPT IMMUNOHAEMATOL, 2300 RC LEIDEN, NETHERLANDS

[2] UNIV LEIDEN HOSP, BLOOD BANK, 2300 RC LEIDEN, NETHERLANDS

[3] UNIV VIRGINIA, DEPT CHEM, CHARLOTTESVILLE, VA 22903 USA

[4] UNIV VIRGINIA, DEPT PATHOL, CHARLOTTESVILLE, VA 22903 USA

[5] UNIV VIRGINIA, DEPT MICROBIOL, CHARLOTTESVILLE, VA 22908 USA

[6] UNIV VIRGINIA, BEIRNE CARTER CTR IMMUNOL RES, CHARLOTTESVILLE, VA 22908 USA

来源：

SCIENCE | 1995年 / 268卷 / 5216期

关键词：

D O I：

10.1126/science.7539551

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.

引用

页码：1476 / 1480

页数：5

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