LIPIODOL UPTAKE AND RETENTION BY HUMAN HEPATOMA-CELLS

被引：41

作者：

CHOU, FI

FANG, KC

CHUNG, C

LUI, WY

CHI, CW

LIU, RS

CHAN, WK

机构：

[1] NATL TSING HUA UNIV, INST NUCL SCI, HSINCHU 30043, TAIWAN

[2] VET GEN HOSP, TAIPEI 11217, TAIWAN

[3] ACAD SINICA, INST BIOMED SCI, TAIPEI 11529, TAIWAN

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1995年 / 22卷 / 03期

关键词：

D O I：

10.1016/0969-8051(94)00112-W

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Lipiodol has important diagnostic and therapeutic uses in hepatoma. However, the mechanisms of its selective, prolonged retention in hepatoma cells is not well understood. Therefore, using oil-red O, light and electron microscopy and neutron activation analysis we have determined that HepG2 cells are characterized by lipiodol deposition and emulsification on the cell surface, action uptake of lipodol by endocytosis, and prolonged intracellular retention. These findings may have major clinical significance in the development of a new treatment for hepatoma patients.

引用

页码：379 / 386

页数：8

共 34 条

[1] HEPATIC-ARTERY INJECTION OF I-131-LABELED LIPIODOL .2. PRELIMINARY-RESULTS OF THERAPEUTIC USE IN PATIENTS WITH HEPATOCELLULAR-CARCINOMA AND LIVER METASTASES [J].