COMPARISON OF THE BIOLOGICAL EFFECTS OF SELECTED 5,8-DIDEAZAFOLATE ANALOGS WITH THEIR 2-DESAMINO COUNTERPARTS

被引：13

作者：

HYNES, JB ^{[1
]}

PATIL, SA ^{[1
]}

HAGAN, RL ^{[1
]}

COLE, A ^{[1
]}

KOHLER, W ^{[1
]}

FREISHEIM, JH ^{[1
]}

机构：

[1] MED COLL OHIO, DEPT BIOCHEM, TOLEDO, OH 43699 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 04期

关键词：

D O I：

10.1021/jm00124a019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：852 / 856

页数：5

共 25 条

[1]

ALLEGRA CJ, 1985, J BIOL CHEM, V260, P9720

[2] AN ANTIMALARIAL ALKALOID FROM HYDRANGEA .14. SYNTHESIS OF 5-MONOSUBSTITUTED, 6-MONOSUBSTITUTED, 7-MONOSUBSTITUTED, AND 8-MONOSUBSTITUTED DERIVATIVES [J].

BAKER, BR ;

SCHAUB, RE ;

JOSEPH, JP ;

MCEVOY, FJ ;

WILLIAMS, JH .

JOURNAL OF ORGANIC CHEMISTRY, 1952, 17 (01) :141-148

[3] Researches on quinazolines (thirtieth paper). A study of the bromination and nitration of 4-quinazolones; The corresponding aminoquinazolones, and certain other new 4-quinazolones. [J].

Bogert, MT ;

Geiger, GA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1912, 34 :524-534

[4] A PHASE-I EVALUATION OF THE QUINAZOLINE ANTIFOLATE THYMIDYLATE SYNTHASE INHIBITOR, N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, CB3717 [J].

CALVERT, AH ;

ALISON, DL ;

HARLAND, SJ ;

ROBINSON, BA ;

JACKMAN, AL ;

JONES, TR ;

NEWELL, DR ;

SIDDIK, ZH ;

WILTSHAW, E ;

MCELWAIN, TJ ;

SMITH, IE ;

HARRAP, KR .

JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (08) :1245-1252

[5]

CHENG YC, 1985, CANCER RES, V45, P598

[6] PURIFICATION AND CHARACTERIZATION OF DIHYDROFOLATE-REDUCTASE FROM METHOTREXATE-RESISTANT HUMAN-LYMPHOBLASTOID CELLS [J].

DELCAMP, TJ ;

SUSTEN, SS ;

BLANKENSHIP, DT ;

FREISHEIM, JH .

BIOCHEMISTRY, 1983, 22 (03) :633-639

[7]

FERNANDES DJ, 1983, CANCER RES, V43, P1117

[8] INHIBITION OF MURINE THYMIDYLATE SYNTHASE AND HUMAN DIHYDROFOLATE-REDUCTASE BY 5,8-DIDEAZA ANALOGS OF FOLIC-ACID AND AMINOPTERIN [J].

HYNES, JB ;

PATIL, SA ;

TOMAZIC, A ;

KUMAR, A ;

PATHAK, A ;

TAN, XH ;

LI, XQ ;

RATNAM, M ;

DELCAMP, TJ ;

FREISHEIM, JH .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (02) :449-454

[9]

HYNES JB, 1986, CANCER CHEMOTH PHARM, V18, P231

[10] IMPROVED SYNTHESIS AND ANTITUMOR EVALUATION OF 5,8-DIDEAZAISOFOLIC ACID AND CLOSELY RELATED ANALOGS [J].

HYNES, JB ;

YANG, YCS ;

MCGILL, JE ;

HARMON, SJ ;

WASHTIEN, WL .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (02) :232-235

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