INHIBITION OF MURINE THYMIDYLATE SYNTHASE AND HUMAN DIHYDROFOLATE-REDUCTASE BY 5,8-DIDEAZA ANALOGS OF FOLIC-ACID AND AMINOPTERIN

被引：22

作者：

HYNES, JB ^{[1
]}

PATIL, SA ^{[1
]}

TOMAZIC, A ^{[1
]}

KUMAR, A ^{[1
]}

PATHAK, A ^{[1
]}

TAN, XH ^{[1
]}

LI, XQ ^{[1
]}

RATNAM, M ^{[1
]}

DELCAMP, TJ ^{[1
]}

FREISHEIM, JH ^{[1
]}

机构：

[1] MED COLL OHIO, DEPT BIOCHEM, TOLEDO, OH 43699 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 02期

关键词：

D O I：

10.1021/jm00397a031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：449 / 454

页数：6

共 26 条

[1] ACHARYA SP, 1975, J HETEROCYCLIC CHEM, V12, P632
[2] ANALOGS OF TETRAHYDROFOLIC ACID .39(1,2). SELECTIVE BROMOACYLATION OF POLYFUNCTIONAL MOLECULES FOR SYNTHESIS OF ACTIVE-SITE-DIRECTED IRREVERSIBLE ENZYME INHIBITORS
BAKER, BR
SANTI, DV
COWARD, JK
SHAPIRO, HS
JORDAAN, JH
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1966, 3 (04) : 425 - &
[3] FOLATE ANALOGS AS INHIBITORS OF THYMIDYLATE SYNTHASE
BRIXNER, DI
UEDA, T
CHENG, YC
HYNES, JB
BROOM, AD
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (04) : 675 - 678
[4] A PHASE-I EVALUATION OF THE QUINAZOLINE ANTIFOLATE THYMIDYLATE SYNTHASE INHIBITOR, N-10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, CB3717
CALVERT, AH
ALISON, DL
HARLAND, SJ
ROBINSON, BA
JACKMAN, AL
JONES, TR
NEWELL, DR
SIDDIK, ZH
WILTSHAW, E
MCELWAIN, TJ
SMITH, IE
HARRAP, KR
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (08) : 1245 - 1252
[5] PREPARATION AND ABSORPTION SPECTRA OF P-MERCAPTOCINNAMIC AND P-MERCAPTOBENZOIC ACIDS AND DERIVATIVES
CAMPAIGNE, E
MEYER, WW
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1962, 27 (08) : 2835 - &
[6] CARLIN SC, 1974, MOL PHARMACOL, V10, P194
[7] CHENG YC, 1985, CANCER RES, V45, P598
[8] PURIFICATION AND CHARACTERIZATION OF DIHYDROFOLATE-REDUCTASE FROM METHOTREXATE-RESISTANT HUMAN-LYMPHOBLASTOID CELLS
DELCAMP, TJ
SUSTEN, SS
BLANKENSHIP, DT
FREISHEIM, JH
[J]. BIOCHEMISTRY, 1983, 22 (03) : 633 - 639
[9] FERNANDES DJ, 1983, CANCER RES, V43, P1117
[10] SYNTHESIS OF QUINAZOLINE ANALOGS OF ISOFOLIC ACID
HYNES, JB
GARRETT, CM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (06) : 632 - 634

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