FOS PROTEIN EXPRESSION IN THE NUCLEUS OF THE SOLITARY TRACT IN RESPONSE TO INTESTINAL NUTRIENTS IN AWAKE RATS

被引：65

作者：

ZITTEL, TT

DEGIORGIO, R

STERNINI, C

RAYBOULD, HE

机构：

[1] UNIV CALIF LOS ANGELES,W LOS ANGELES VET AFFAIRS MED CTR,CTR GASTROCNTER BIOL,CURE,DEPT MED,LOS ANGELES,CA

[2] UNIV CALIF LOS ANGELES,W LOS ANGELES VET AFFAIRS MED CTR,CTR GASTROCNTER BIOL,CURE,DEPT PHYSIOL,LOS ANGELES,CA

[3] UNIV CALIF LOS ANGELES,W LOS ANGELES VET AFFAIRS MED CTR,CTR GASTROCNTER BIOL,CURE,LOS ANGELES,CA

[4] UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA

来源：

BRAIN RESEARCH | 1994年 / 663卷 / 02期

关键词：

NUCLEUS OF THE SOLITARY TRACT; FOS-LIKE IMMUNOREACTIVITY; IMMUNOCYTOCHEMISTRY; SMALL INTESTINE; LIPID; CARBOHYDRATE;

D O I：

10.1016/0006-8993(94)91272-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nutrients in the intestine inhibit food intake via an action on the vagal afferent pathway. The aim of the present study was to use immunochemical detection of Fos protein-like immunoreactivity (FLI) in the brainstem to trace the neuronal pathways activated by intestinal nutrients. Perfusion of the intestine of awake rats via an indwelling duodenal catheter with iso-osmotic mannitol, hydrochloric acid or casein hydrolysate had no effect on the number of FLI neurons in the nucleus of the solitary tract (NTS). Lipid emulsion (20%) and 2.7 M glucose significantly increased the number of immunopositive cells in the NTS. There was a significant increase in the number of immunopositive cells from caudal to rostral NTS. Nutrients effective at decreasing food intake (carbohydrate and fat) produced significant increases in Fos-like immunopositive cells in the NTS.

引用

页码：266 / 270

页数：5

共 26 条

[1] REPRESENTATION OF THE CECUM IN THE LATERAL DORSAL MOTOR NUCLEUS OF THE VAGUS NERVE AND COMMISSURAL SUBNUCLEUS OF THE NUCLEUS-TRACTUS-SOLITARII IN RAT [J].