THE SIR2 GENE FAMILY, CONSERVED FROM BACTERIA TO HUMANS, FUNCTIONS IN SILENCING, CELL-CYCLE PROGRESSION, AND CHROMOSOME STABILITY

被引：522

作者：

BRACHMANN, CB ^{[1
]}

SHERMAN, JM ^{[1
]}

DEVINE, SE ^{[1
]}

CAMERON, EE ^{[1
]}

PILLUS, L ^{[1
]}

BOEKE, JD ^{[1
]}

机构：

[1] UNIV COLORADO, DEPT MOLEC CELLULAR & DEV BIOL, BOULDER, CO 80309 USA

来源：

GENES & DEVELOPMENT | 1995年 / 9卷 / 23期

关键词：

HST GENES; SACCHAROMYCES CEREVISIAE; TELOMERIC SILENCING; HOMOLOGOUS RECOMBINATION; CHROMOSOME SEGREGATION;

D O I：

10.1101/gad.9.23.2888

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is known about conserved mechanisms of silencing. We report here the discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals. At least three HST genes can function in silencing; HST1 overexpression restores transcriptional silencing to a sir2 mutant and hst3 hst4 double mutants are defective in telomeric silencing. In addition, HST3 and HST4 together contribute to proper cell cycle progression, radiation resistance, and genomic stability, establishing new connections between silencing and these fundamental cellular processes.

引用

页码：2888 / 2902

页数：15

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