ENZYMATIC STUDIES OF THE EFFECT OF CU (II) ON OXYGEN RADICAL PRODUCTION STIMULATED BY DAUNORUBICIN AND AMETANTRONE

被引：5

作者：

TARASIUK, J ^{[1
]}

KOLODZIEJCZYK, P ^{[1
]}

BOROWSKI, E ^{[1
]}

机构：

[1] GDANSK TECH UNIV,DEPT PHARMACEUT TECHNOL & BIOCHEM,PL-80952 GDANSK,POLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1990年 / 39卷 / 09期

关键词：

D O I：

10.1016/0006-2952(90)90421-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Daunorubicin can bind Cu (II) in Tris-HCl buffer (pH 7.4) and in the presence of NADH (100 μM). The complex is very stable. Cu (II) is not removed from the complex by cytochrome c reductase. The complexation of Cu (II) to daunorubicin gives rise to a modification of its redox properties. The complex, unlike the free drug, does not stimulate oxygen radical production. Ametantrone can also form a complex with Cu (II) in the conditions of enzymatic assays. Nevertheless, this complex is not stable in the presence of cytochrome c reductase. It dissociates immediately after the addition of the enzyme with releasing the metal ion. © 1990.

引用

页码：1405 / 1410

页数：6