RELAXATION RESPONSE TO PINACIDIL AND DIAZOXIDE IN THE MOUSE ISOLATED DISTAL COLON

被引：10

作者：

LEBRUN, P ^{[1
]}

FONTAINE, J ^{[1
]}

机构：

[1] FREE UNIV BRUSSELS,FAC MED & PHARM,PHARMACOL LAB,B-1000 BRUSSELS,BELGIUM

来源：

PHARMACOLOGY | 1990年 / 40卷 / 01期

关键词：

D O I：

10.1159/000138634

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pinacidil and diazoxide induced concentration-related relaxations of the longitudinal muscle of the mouse distal colon. The relaxing effects of pinacidil and diazoxide were unaffected by tetraethylammonium, but were antagonized by tolbutamide and glibenclamide. Relaxations provoked by nifedipine were not counteracted by the two hypoglycaemic sulfonylureas. It is tempting to suggest that the relaxation response to pinacidil and diazoxide could reflect the ability of both compounds to interfere with membrane K+ channels sharing common pharmacological properties with the K+(ATP) channels recently described in other tissues.

引用

页码：21 / 26

页数：6

共 17 条

[1] CHANGES OF MEMBRANE CURRENTS IN CARDIAC-CELLS INDUCED BY LONG WHOLE-CELL RECORDINGS AND TOLBUTAMIDE [J].

BELLES, B ;

HESCHELER, J ;

TRUBE, G .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1987, 409 (06) :582-588

[2] EVIDENCE THAT THE MECHANISM OF THE INHIBITORY-ACTION OF PINACIDIL IN RAT AND GUINEA-PIG SMOOTH-MUSCLE DIFFERS FROM THAT OF GLYCERYL TRINITRATE [J].

BRAY, KM ;

NEWGREEN, DT ;

SMALL, RC ;

SOUTHERTON, JS ;

TAYLOR, SG ;

WEIR, SW ;

WESTON, AH .

BRITISH JOURNAL OF PHARMACOLOGY, 1987, 91 (02) :421-429

[3] PINACIDIL MONOHYDRATE - A NOVEL VASODILATOR - REVIEW OF PRECLINICAL PHARMACOLOGY AND MECHANISM OF ACTION [J].

COHEN, ML .

DRUG DEVELOPMENT RESEARCH, 1986, 9 (04) :249-258

[4] SIMILARITIES IN THE MECHANISM OF ACTION OF 2 NEW VASODILATOR DRUGS - PINACIDIL AND BRL-34915 [J].

COOK, NS ;

QUAST, U ;

HOF, RP ;

BAUMLIN, Y ;

PALLY, C .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1988, 11 (01) :90-99

[5] THE PHARMACOLOGY OF POTASSIUM CHANNELS AND THEIR THERAPEUTIC POTENTIAL [J].

COOK, NS .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (01) :21-28

[6] GLIBENCLAMIDE IS A COMPETITIVE ANTAGONIST OF CROMAKALIM, PINACIDIL AND RP-49356 IN GUINEA-PIG PULMONARY-ARTERY [J].

ELTZE, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 165 (2-3) :231-239

[7] PHARMACOLOGICAL ANALYSIS OF THE EFFECTS OF BAY K-8644 AND ORGANIC CALCIUM-ANTAGONISTS ON THE MOUSE ISOLATED DISTAL COLON [J].

FONTAINE, J ;

LEBRUN, P .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 94 (04) :1198-1206

[8] CONTRACTILE EFFECTS OF SUBSTANCE-P AND OTHER TACHYKININS ON THE MOUSE ISOLATED DISTAL COLON [J].

FONTAINE, J ;

LEBRUN, P .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 96 (03) :583-590

[9]

FOSSET M, 1988, J BIOL CHEM, V263, P7933

[10] EFFECTS OF TETRODOTOXIN ON INNERVATED SMOOTH MUSCLE PREPARATIONS [J].

GERSHON, MD .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1967, 29 (03) :259-&

← 1 2 →