ACUTE-LEUKEMIA WITH A TRANSLOCATION T(4-11)(Q21-Q23) - A DISTINCT CLINICOPATHOLOGICAL ENTITY - REPORT OF A CASE WITH CYTOGENETIC CLONAL EVOLUTION AND REVIEW OF 146 CASES OF THE LITERATURE

被引：7

作者：

LEGLISE, MC

RIVIERE, D

BRIERE, J

机构：

[1] Hematology Laboratory Centre Hospitalier Universitaire de Brest, Centre d'Ecologie Cellulaire, Hôpital de la Salpétriétre, Paris

[2] Cytogenetics Laboratory Centre Hospitalier Universitaire de Brest, Centre d'Ecologie Cellulaire, Hôpital de la Salpétriétre, Paris

[3] Department of Onco-Hematology Centre Hospitalier Universitaire de Brest, Centre d'Ecologie Cellulaire, Hôpital de la Salpétriétre, Paris

来源：

LEUKEMIA & LYMPHOMA | 1990年 / 2卷 / 06期

关键词：

Acute leukemia; Chromosome; 11; 4; Clonal evolution; Phenotype; Translocation;

D O I：

10.3109/10428199009069288

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We present a cytogenetic clonal evolution that correlates morphological and immunological shifts in a case of a patient with a t(4;11) (q21;q23) acute leukemia. We take this opportunity to review 146 cases reported so far, with special reference to morphology, immunophenotyping, cytogenetics, clinical characteristics and evolution. Particular features are underlined, and prognosis, leukemic stem cell origin, chromosomal breakpoints and genes involved are discussed. A relationship between this type of leukemia and exposure to carcinogens is suggested by a high rate of secondary leukemia in adults and a high frequency in newborns and infants. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：353 / 368

页数：16

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