2-CHLOROADENOSINE DECREASES LONG-TERM POTENTIATION IN THE HIPPOCAMPAL CA1 AREA OF THE RAT

被引：49

作者：

DEMENDONCA, A

RIBEIRO, JA

机构：

[1] GULBENKIAN INST SCI,PHARMACOL LAB,P-2781 OEIRAS,PORTUGAL

[2] HOSP SANTA MARIA,CTR ESTUDOS EGAS MONIZ,LISBON,PORTUGAL

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 01期

关键词：

2-Chloroadenosine; Adenosine; CA1; area; Hippocampus; Long-term potentiation; Rat;

D O I：

10.1016/0304-3940(90)90260-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the adenosine (ADO) analogue 2-chloroadenosine (CADO) on frequency-induced long-term potentiation (LTP) of the responses evoked by stimulation of the Schaffer fibres and recorded in CA1 area was studied in hippocampal slices of the rat. CADO significantly decreased LTP of the population spikes (PS) (EC50 = 0.28 μM), and LTP of the field excitatory postsynaptic potentials (f.e.p.s.p) (EC50 = 0.33 μM). These effects were reversed by the ADO receptor antagonist 8-phenyltheophylline (8-PT) (2.5 μM). It is concluded that CADO decreases LTP through activation of a xanthine-sensitive ADO receptor. © 1990.

引用

收藏

页码：107 / 111

页数：5

相关论文

共 12 条

[1] CORRELATION BETWEEN LONG-TERM POTENTIATION AND RELEASE OF ENDOGENOUS AMINO-ACIDS FROM DENTATE GYRUS OF ANESTHETIZED RATS [J].

BLISS, TVP ;

DOUGLAS, RM ;

ERRINGTON, ML ;

LYNCH, MA .

JOURNAL OF PHYSIOLOGY-LONDON, 1986, 377 :391-408

[2] REGULATION OF GLUTAMATE AND ASPARTATE RELEASE FROM SLICES OF THE HIPPOCAMPAL CA1 AREA - EFFECTS OF ADENOSINE AND BACLOFEN [J].

BURKE, SP ;

NADLER, JV .

JOURNAL OF NEUROCHEMISTRY, 1988, 51 (05) :1541-1551

[3]

DALY JW, 1983, PHYSL PHARM ADENOSIN, P275

[4] THE ADENOSINE AGONIST 2-CHLOROADENOSINE INHIBITS THE INDUCTION OF LONG-TERM POTENTIATION OF THE PERFORANT PATH [J].

DOLPHIN, AC .

NEUROSCIENCE LETTERS, 1983, 39 (01) :83-89

[5] ADENINE-NUCLEOTIDES AND SYNAPTIC TRANSMISSION IN THE INVITRO RAT HIPPOCAMPUS [J].

DUNWIDDIE, TV ;

HOFFER, BJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1980, 69 (01) :59-68

[6] ADENOSINE ENHANCES AFTERHYPERPOLARIZATION AND ACCOMMODATION IN HIPPOCAMPAL PYRAMIDAL CELLS [J].

HAAS, HL ;

GREENE, RW .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1984, 402 (03) :244-247

[7] POSTSYNAPTIC CALCIUM IS SUFFICIENT FOR POTENTIATION OF HIPPOCAMPAL SYNAPTIC TRANSMISSION [J].

MALENKA, RC ;

KAUER, JA ;

ZUCKER, RS ;

NICOLL, RA .

SCIENCE, 1988, 242 (4875) :81-84

[8] ADENINE DERIVATIVES AS NEUROHUMORAL AGENTS IN BRAIN - QUANTITIES LIBERATED ON EXCITATION OF SUPERFUSED CEREBRAL TISSUES [J].

PULL, I ;

MCILWAIN, H .

BIOCHEMICAL JOURNAL, 1972, 130 (04) :975-981

[9] ADENOSINE RECEPTORS AND CALCIUM - BASIS FOR PROPOSING A 3RD (A3) ADENOSINE RECEPTOR [J].

RIBEIRO, JA ;

SEBASTIAO, AM .

PROGRESS IN NEUROBIOLOGY, 1986, 26 (03) :179-209

[10] PHYSIOLOGICAL MODULATION BY ADENOSINE - SELECTIVE BLOCKADE OF A1-RECEPTORS WITH DPCPX ENHANCES STIMULUS TRAIN-EVOKED NEURONAL CA INFLUX IN RAT HIPPOCAMPAL SLICES [J].

SCHUBERT, P .

BRAIN RESEARCH, 1988, 458 (01) :162-165