2-CHLOROADENOSINE DECREASES LONG-TERM POTENTIATION IN THE HIPPOCAMPAL CA1 AREA OF THE RAT

被引：49

作者：

DEMENDONCA, A

RIBEIRO, JA

机构：

[1] GULBENKIAN INST SCI,PHARMACOL LAB,P-2781 OEIRAS,PORTUGAL

[2] HOSP SANTA MARIA,CTR ESTUDOS EGAS MONIZ,LISBON,PORTUGAL

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 01期

关键词：

2-Chloroadenosine; Adenosine; CA1; area; Hippocampus; Long-term potentiation; Rat;

D O I：

10.1016/0304-3940(90)90260-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the adenosine (ADO) analogue 2-chloroadenosine (CADO) on frequency-induced long-term potentiation (LTP) of the responses evoked by stimulation of the Schaffer fibres and recorded in CA1 area was studied in hippocampal slices of the rat. CADO significantly decreased LTP of the population spikes (PS) (EC50 = 0.28 μM), and LTP of the field excitatory postsynaptic potentials (f.e.p.s.p) (EC50 = 0.33 μM). These effects were reversed by the ADO receptor antagonist 8-phenyltheophylline (8-PT) (2.5 μM). It is concluded that CADO decreases LTP through activation of a xanthine-sensitive ADO receptor. © 1990.

引用

页码：107 / 111

页数：5