ADRENOLEUKODYSTROPHY - A CORRELATION BETWEEN SATURATED VERY LONG-CHAIN FATTY-ACIDS IN MONONUCLEAR-CELLS AND PHENOTYPE

被引：9

作者：

ANTOKU, Y ^{[1
]}

KOIKE, F ^{[1
]}

OHTSUKA, Y ^{[1
]}

SAKAI, T ^{[1
]}

TSUKAMOTO, K ^{[1
]}

NAGARA, H ^{[1
]}

IWASHITA, H ^{[1
]}

GOTO, I ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC MED,INST NEUROL,DEPT NEUROL,FUKUOKA 812,JAPAN

来源：

ANNALS OF NEUROLOGY | 1991年 / 30卷 / 01期

关键词：

D O I：

10.1002/ana.410300118

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Saturated very long-chain fatty acids in erythrocyte membranes, blood plasma, and mononuclear cells were studied in 4 patients with childhood-adolescent adrenoleukodystrophy and 4 patients with adult adrenoleukodystrophy and 19 normal control subjects by using high-performance liquid chromatography. Ratios of C26:0 to C22:0 in mononuclear cells, erythrocyte membranes, and blood plasma in patients with childhood-adolescent and adult adrenoleukodystrophy were significantly higher than in normal control subjects. Furthermore, ratios of C26:0 to C22:0 in mononuclear cells were significantly higher in patients with childhood-adolescent adrenoleukodystrophy than in patients with adult adrenoleukodystrophy, whereas there was no significant difference in the ratios in erythrocyte membranes and blood plasma between the two groups of patients with adrenoleukodystrophy. These results suggest that there is a correlation between phenotype and ratio of C26:0 to C22:0 within mononuclear cells in patients with adrenoleukodystrophy.

引用

页码：101 / 103

页数：3

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