PRENATAL COCAINE EXPOSURE - INCREASED STRIATAL DOPAMINE TRANSPORTER BINDING IN OFFSPRING AT 3 AND 6 MONTHS OF AGE

被引：22

作者：

KOFF, JM ^{[1
]}

MILLER, LG ^{[1
]}

机构：

[1] TUFTS UNIV, SCH MED, DEPT PHARMACOL & EXPTL THERAPEUT, BOSTON, MA 02111 USA

来源：

BRAIN RESEARCH BULLETIN | 1994年 / 33卷 / 02期

关键词：

COCAINE; PRENATAL; DOPAMINE TRANSPORTER;

D O I：

10.1016/0361-9230(94)90256-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prior studies indicate that prenatal cocaine exposure can alter dopamine transporter binding in mature mice. To determine the persistence of these effects, pregnant mice were treated with cocaine, 10 mg/kg/d, during days 13 to 20 of gestation and dopamine transporter binding was evaluated in offspring at 3 and 6 months of age. In contrast to prior studies, binding in striatum was significantly increased at both time points in cocaine-exposed mice compared to controls.

引用

页码：223 / 224

页数：2

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