BIOLOGY OF PEDIATRIC PERIPHERAL NEUROECTODERMAL TUMORS

被引：51

作者：

THIELE, CJ

机构：

[1] Molecular Genetics Section, Pediatric Branch, National Cancer Institute, Bethesda, Maryland

来源：

CANCER AND METASTASIS REVIEWS | 1991年 / 10卷 / 04期

关键词：

NEUROBLASTOMA; NEUROEPITHELIOMA; EWINGS SARCOMA; RETINOIC ACID; DIFFERENTIATION;

D O I：

10.1007/BF00554793

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The pediatric peripheral neuroectodermal tumors which include neuroblastoma, peripheral neuroepithelioma and Ewing's sarcoma may correspond to distinct neural crest cell lineages or tumors arrested at different stages of neural crest development. Besides a brief commentary on the salient clinical features of these tumors, this review examines how cell and molecular biological studies have contributed to a re-classification of these tumors. The differentiation of these tumors is reviewed with a particular emphasis on retinoic acid induced differentiation of neuroblastoma as a model to identify genes important in controlling cell growth, suppression of tumorigenicity and induction of differentiation.

引用

页码：311 / 319

页数：9

共 44 条

[31]

LEDOUARIN N, 1981, NEURAL CREST

[32]

LIPINSKI M, 1987, CANCER RES, V47, P1983

[33] CELLULAR DNA CONTENT AS A PREDICTOR OF RESPONSE TO CHEMOTHERAPY IN INFANTS WITH UNRESECTABLE NEURO-BLASTOMA [J].