SYNTHESIS OF OPTICALLY PURE (R)-ALPHA-TRIFLUOROMETHYL-ALANINE AND (S)-ALPHA-TRIFLUOROMETHYL-ALANINE

被引：74

作者：

BRAVO, P ^{[1
]}

CAPELLI, S ^{[1
]}

MEILLE, SV ^{[1
]}

VIANI, F ^{[1
]}

ZANDA, M ^{[1
]}

KUKHAR, VP ^{[1
]}

SOLOSHONOK, VA ^{[1
]}

机构：

[1] UKRAINIAN ACAD SCI,INST BIOORGAN CHEM & PETROCHEM,KIEV 252660,UKRAINE

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(00)86276-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(+)-(R)- and (-)-(S)-3,3,3-trifluoro-2-methyl-alanine (1) were synthesized from (+)-(R)-methyl-p-tolylsulphoxide (5) and N-alkoxycarbonylimino derivatives 4 of methyl 3,3,3-trifluoropyruvate (3). The absolute configuration was determined by X-ray analyses of two synthetic intermediates (2S,R(S))-6a and (2R,R(S))-6c.

引用

页码：2009 / 2018

页数：10

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