INHIBITION OF HIV-REPLICATION BY 3'-FLUORO-MODIFIED NUCLEOSIDES WITH LOW CYTO-TOXICITY

被引：37

作者：

MATTHES, E ^{[1
]}

LEHMANN, C ^{[1
]}

VONJANTALIPINSKI, M ^{[1
]}

SCHOLZ, D ^{[1
]}

机构：

[1] HUMBOLDT UNIV,INST MED VIROL,DDR-1040 BERLIN,GER DEM REP

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1989年 / 165卷 / 01期

关键词：

D O I：

10.1016/0006-291X(89)91096-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：488 / 495

页数：8

共 16 条

[1] 5-CHLORO-SUBSTITUTED DERIVATIVES OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYURIDINE, 3'-FLUORO-2',3'-DIDEOXYURIDINE AND 3'-AZIDO-2',3'-DIDEOXYURIDINE AS ANTI-HIV AGENTS [J].

BALZARINI, J ;

VANAERSCHOT, A ;

HERDEWIJN, P ;

DECLERCQ, E .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (06) :869-874

[2] ANTI-RETROVIRUS ACTIVITY OF 3'-FLUORO-SUBSTITUTED AND 3'-AZIDO-SUBSTITUTED PYRIMIDINE 2',3'-DIDEOXYNUCLEOSIDE ANALOGS [J].

BALZARINI, J ;

BABA, M ;

PAUWELS, R ;

HERDEWIJN, P ;

DECLERCO, E .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (14) :2847-2856

[3] AN ANALYSIS OF THE INHIBITION OF REPLICATION OF HIV AND MULV BY SOME 3'-BLOCKED PYRIMIDINE ANALOGS [J].

BAZIN, H ;

CHATTOPADHYAYA, J ;

DATEMA, R ;

ERICSON, AC ;

GILLJAM, G ;

JOHANSSON, NG ;

HANSEN, J ;

KOSHIDA, R ;

MOELLING, K ;

OBERG, B ;

REMAUD, G ;

STENING, G ;

VRANG, L ;

WAHREN, B ;

WU, JC .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (01) :109-119

[4]

CHENG YC, 1987, J BIOL CHEM, V262, P2187

[5]

HANSEN J, 1987, J BIOL CHEM, V262, P12393

[6] INFECTION OF HTLV-III/LAV IN HTLV-I-CARRYING CELLS MT-2 AND MT-4 AND APPLICATION IN A PLAQUE-ASSAY [J].

HARADA, S ;

KOYANAGI, Y ;

YAMAMOTO, N .

SCIENCE, 1985, 229 (4713) :563-566

[7] ENHANCED INVITRO INHIBITION OF HIV-1 REPLICATION BY 3'-FLUORO-3'-DEOXYTHYMIDINE COMPARED TO SEVERAL OTHER NUCLEOSIDE ANALOGS [J].

HARTMANN, H ;

VOGT, MW ;

DURNO, AG ;

HIRSCH, MS ;

HUNSMANN, G ;

ECKSTEIN, F .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1988, 4 (06) :457-466

[8]

MATTHES E, 1985, BIOMED BIOCHIM ACTA, V44, pK63

[9] PHOSPHORYLATION, ANTI-HIV ACTIVITY AND CYTO-TOXICITY OF 3'-FLUOROTHYMIDINE [J].

MATTHES, E ;

LEHMANN, C ;

SCHOLZ, D ;

ROSENTHAL, HA ;

LANGEN, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 153 (02) :825-831

[10] INHIBITION OF HIV-ASSOCIATED REVERSE-TRANSCRIPTASE BY SUGAR-MODIFIED DERIVATIVES OF THYMIDINE 5'-TRIPHOSPHATE IN COMPARISON TO CELLULAR DNA POLYMERASE-ALPHA AND POLYMERASE-BETA [J].

MATTHES, E ;

LEHMANN, C ;

SCHOLZ, D ;

VONJANTALIPINSKI, M ;

GAERTNER, K ;

ROSENTHAL, HA ;

LANGEN, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (01) :78-85

← 1 2 →