MULTINUCLEAR NMR CHARACTERIZATION OF 2 COEXISTING CONFORMATIONAL STATES OF THE LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE TRIMETHOPRIM NADP+ COMPLEX

被引:46
作者
BIRDSALL, B [1 ]
BEVAN, AW [1 ]
PASCUAL, C [1 ]
ROBERTS, GCK [1 ]
FEENEY, J [1 ]
GRONENBORN, A [1 ]
CLORE, GM [1 ]
机构
[1] NATL INST MED RES, DIV PHYS BIOCHEM, MILL HILL, LONDON NW7 1AA, ENGLAND
关键词
D O I
10.1021/bi00315a032
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:4733 / 4742
页数:10
相关论文
共 51 条
[1]   USE OF TRANSFERRED NUCLEAR OVERHAUSER EFFECTS IN THE STUDY OF THE CONFORMATIONS OF SMALL MOLECULES BOUND TO PROTEINS [J].
ALBRAND, JP ;
BIRDSALL, B ;
FEENEY, J ;
ROBERTS, GCK ;
BURGEN, ASV .
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1979, 1 (01) :37-41
[2]   INHIBITION OF DIHYDROFOLATE-REDUCTASE - EFFECT OF REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE ON THE SELECTIVITY AND AFFINITY OF DIAMINOBENZYLPYRIMIDINES [J].
BACCANARI, DP ;
DALUGE, S ;
KING, RW .
BIOCHEMISTRY, 1982, 21 (20) :5068-5075
[3]   THE BINDING OF TRIMETHOPRIM TO BACTERIAL DIHYDROFOLATE-REDUCTASE [J].
BAKER, DJ ;
BEDDELL, CR ;
CHAMPNESS, JN ;
GOODFORD, PJ ;
NORRINGTON, FEA ;
SMITH, DR ;
STAMMERS, DK .
FEBS LETTERS, 1981, 126 (01) :49-52
[4]  
BAKER DJ, 1983, CHEM BIOL PTERIDINES, P545
[5]  
BEVAN AW, 1983, CHEM BIOL PTERIDINES, P557
[6]   EFFECTS OF COENZYME ANALOGS ON THE BINDING OF PARA-AMINOBENZOYL-L-GLUTAMATE AND 2,4-DIAMINOPYRIMIDINE TO LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE [J].
BIRDSALL, B ;
BURGEN, ASV ;
ROBERTS, GCK .
BIOCHEMISTRY, 1980, 19 (16) :3732-3737
[7]   H-1 NUCLEAR MAGNETIC-RESONANCE STUDIES OF LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE - EFFECTS OF SUBSTRATE AND INHIBITOR BINDING ON HISTIDINE RESIDUES [J].
BIRDSALL, B ;
GRIFFITHS, DV ;
ROBERTS, GCK ;
FEENEY, J ;
BURGEN, A .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1977, 196 (1124) :251-265
[8]   BINDING OF COENZYME ANALOGS TO LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE - BINARY AND TERNARY COMPLEXES [J].
BIRDSALL, B ;
BURGEN, ASV ;
ROBERTS, GCK .
BIOCHEMISTRY, 1980, 19 (16) :3723-3731
[9]   TRIMETHOPRIM BINDING TO BACTERIAL AND MAMMALIAN DIHYDROFOLATE-REDUCTASE - A COMPARISON BY PROTON AND C-13 NUCLEAR MAGNETIC-RESONANCE [J].
BIRDSALL, B ;
ROBERTS, GCK ;
FEENEY, J ;
DANN, JG ;
BURGEN, ASV .
BIOCHEMISTRY, 1983, 22 (24) :5597-5604
[10]  
BIRDSALL B, 1984, J MED CHEM