SPINAL OPIOID RECEPTORS AND INHIBITION OF URINARY-BLADDER MOTILITY INVIVO

被引：29

作者：

DRAY, A ^{[1
]}

METSCH, R ^{[1
]}

机构：

[1] UNIV ARIZONA, SCH MED, DEPT PHARMACOL, TUCSON, AZ 85724 USA

来源：

NEUROSCIENCE LETTERS | 1984年 / 47卷 / 01期

关键词：

D O I：

10.1016/0304-3940(84)90390-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of intrathecal injections of morphine and other opioid receptor selective drugs were tested on urinary bladder contractions in the anesthetized rat. Morphine produced dose-related inhibition of bladder motility which was abolished by naloxone. This action was also observed with .mu.- and .delta.-opioid receptor agonists but not with .delta.-opioid receptor agonist. These observations appear related to the urinary retention seen clinically with epidural administrations of morphine and support the hypothesis that urinary bladder activity is influenced by spinal opioid mechanisms involving .mu.- and .delta.-opioid receptors.

引用

页码：81 / 84

页数：4

共 15 条

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