SYNTHESIS OF NOVEL 1'-NITROGEN REPLACED CARBOCYCLIC THYMIDINE ANALOGS AS POTENTIAL ANTIAIDS AGENTS

被引：20

作者：

LEE, YH ^{[1
]}

KIM, HK ^{[1
]}

YOUN, IK ^{[1
]}

CHAE, YB ^{[1
]}

机构：

[1] KOREA RES INST CHEM TECHNOL,DIV MED CHEM,DAE DEOG DANJI,POB 9,TAEJON,SOUTH KOREA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)80809-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The racemic, 1'-nitrogen substituted 3'-hydroxy, 3'-azido and 3'-fluoro -2',3'-dideoxy carbocyclic pyrimidine nucleosides were synthesized.

引用

页码：287 / 290

页数：4

共 16 条

[1] SYNTHESIS OF (+/-)-2'-OXA-CARBOCYCLIC-2',3'-DIDEOXYNUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS [J].

BAMFORD, MJ ;

HUMBER, DC ;

STORER, R .

TETRAHEDRON LETTERS, 1991, 32 (02) :271-274

[2] STEREOSPECIFIC SYNTHESIS AND ANTIVIRAL PROPERTIES OF DIFFERENT ENANTIOMERICALLY PURE CARBOCYCLIC 2'-DEOXYRIBONUCLEOSIDE ANALOGS DERIVED FROM COMMON CHIRAL POOLS - (+)-(1R,5S)-2-OXABICYCLO[3.3.0]OCT-6-EN-3-ONE AND (-)-(1S,5R)-2-OXABICYCLO[3.3.0]OCT-6-EN-3-ONE [J].

BERES, J ;

SAGI, G ;

TOMOSKOZI, I ;

GRUBER, L ;

BAITZGACS, E ;

OTVOS, L ;

DECLERCQ, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) :1353-1360

[3] SYNTHESIS OF ENANTIOMERICALLY PURE CARBOCYCLIC 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE, A POTENTIAL ANTI-AIDS DRUG [J].

BODENTEICH, M ;

GRIENGL, H .

TETRAHEDRON LETTERS, 1987, 28 (44) :5311-5312

[4] STRUCTURE ACTIVITY RELATIONSHIPS OF PYRIMIDINE NUCLEOSIDES AS ANTIVIRAL AGENTS FOR HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS [J].

CHU, CK ;

SCHINAZI, RF ;

AHN, MK ;

ULLAS, GV ;

GU, ZP .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (03) :612-617

[5] SYNTHESIS OF COMPOUNDS ACTIVE AGAINST HIV - PREPARATION OF 6'-FLUOROCARBOCYCLIC (3'-DEOXY-3'-AZIDOTHYMIDINE) [J].

FLETCHER, CA ;

HILPERT, H ;

MYERS, PL ;

ROBERTS, SM ;

STORER, R .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (22) :1707-1709

[6] PHOSPHORYLATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE AND SELECTIVE INTERACTION OF THE 5'-TRIPHOSPHATE WITH HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE [J].

FURMAN, PA ;

FYFE, JA ;

STCLAIR, MH ;

WEINHOLD, K ;

RIDEOUT, JL ;

FREEMAN, GA ;

LEHRMAN, SN ;

BOLOGNESI, DP ;

BRODER, S ;

MITSUYA, H ;

BARRY, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8333-8337

[7] SYNTHESIS OF 9-(HYDROXYALKYLAMINO)GUANINES, NOVEL ANTIVIRAL ACYCLONUCLEOSIDES [J].

HARNDEN, MR ;

JARVEST, RL .

TETRAHEDRON LETTERS, 1988, 29 (46) :5995-5998

[8] SYNTHESIS OF 1-(HYDROXYALKOXY)PYRIMIDINES, A NOVEL SERIES OF ACYCLIC NUCLEOSIDE ANALOGS [J].

HARNDEN, MR ;

JENNINGS, LJ ;

PARKIN, A .

TETRAHEDRON LETTERS, 1988, 29 (32) :4013-4016

[9] SYNTHESIS AND ANTIVIRAL ACTIVITY OF 9-ALKOXYPURINES .1. 9-(3-HYDROXYPROPOXY)PURINES AND 9-[3-HYDROXY-2-(HYDROXYMETHYL)PROPOXY]PURINES [J].

HARNDEN, MR ;

WYATT, PG ;

BOYD, MR ;

SUTTON, D .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) :187-196

[10] SYNTHESIS OF ISO-DDA, MEMBER OF A NOVEL CLASS OF ANTI-HIV AGENTS [J].

HURYN, DM ;

SLUBOSKI, BC ;

TAM, SY ;

TODARO, LJ ;

WEIGELE, M .

TETRAHEDRON LETTERS, 1989, 30 (46) :6259-6262

← 1 2 →