4C3HPG (RS-4-CARBOXY-3-HYDROXYPHENYLGLYCINE), A WEAK AGONIST AT METABOTROPIC GLUTAMATE RECEPTORS, OCCLUDES THE ACTION OF TRANS-ACPD IN HIPPOCAMPUS

被引：8

作者：

GERBER, U

GAHWILER, BH

机构：

[1] Brain Research Institute, Unversity of Zürich

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 221卷 / 2-3期

关键词：

METABOTROPIC GLUTAMATE RECEPTORS; 1S; 3R-TRANS-ACPD; HIPPOCAMPAL PYRAMIDAL CELLS;

D O I：

10.1016/0014-2999(92)90733-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The determination of the physiological role of glutamatergic metabotropic actions has been hampered by the lack of potent and specific antagonists. It has recently been reported that 4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine) can antagonize metabotropic responses in the central nervous system. The effects of 4C3HPG on metabotropic responses evoked by trans-ACPD were investigated in CA3 pyramidal cells in hippocampal slice cultures. Our results show that in hippocampus 4C3HPG fails to antagonize responses mediated by metabotropic glutamate receptors.

引用

页码：401 / 402

页数：2

共 6 条

[1] GLUTAMATE MEDIATES A SLOW SYNAPTIC RESPONSE IN HIPPOCAMPAL SLICE CULTURES [J].