EIF-2 KINASES - REGULATORS OF GENERAL AND GENE-SPECIFIC TRANSLATION INITIATION

被引：125

作者：

WEK, RC

机构：

[1] R. C. Wek is at the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 11期

关键词：

D O I：

10.1016/0968-0004(94)90136-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylation of eukaryotic initiation factor-2 (elF-2) is an important mechanism regulating general translation initiation. Two mammalian elf-2 kinases, the double-stranded-RNA-dependent kinase (PKR) and heme-regulated inhibitor kinase (HRI), have been characterized by sequencing, revealing shared sequence and structural features distinct from other eukaryotic protein kinases. Recent work in yeast has shown that a third related kinase, GCN2, also phosphorylates the regulated site in elF-2. However, unlike the mammalian kinases, this kinase regulates gene-specific translation. Current models are presented for the regulation of each elF-2 kinase, and the molecular basis for how this general form of regulation is adapted to control expression of a single species of messenger RNA is discussed.

引用

页码：491 / 496

页数：6

共 38 条

[31]

PATEL RC, 1992, J BIOL CHEM, V267, P7671

[32] MUTATIONS ACTIVATING THE YEAST EIF-2-ALPHA KINASE GCN2 - ISOLATION OF ALLELES ALTERING THE DOMAIN RELATED TO HISTIDYL-TRANSFER-RNA SYNTHETASES [J].

RAMIREZ, M ;

WEK, RC ;

DEALDANA, CRV ;

JACKSON, BM ;

FREEMAN, B ;

HINNEBUSCH, AG .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (12) :5801-5815

[33] TRANSCRIPTIONAL-TRANSLATIONAL REGULATORY CIRCUIT IN SACCHAROMYCES-CEREVISIAE WHICH INVOLVES THE GCN4 TRANSCRIPTIONAL ACTIVATOR AND THE GCN2 PROTEIN-KINASE [J].

ROUSSOU, I ;

THIREOS, G ;

HAUGE, BM .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (05) :2132-2139

[34]

ROWLANDS AG, 1988, J BIOL CHEM, V263, P5526

[35] A CONSERVED DOUBLE-STRANDED RNA-BINDING DOMAIN [J].

STJOHNSTON, D ;

BROWN, NH ;

GALL, JG ;

JANTSCH, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :10979-10983

[36] JUXTAPOSITION OF DOMAINS HOMOLOGOUS TO PROTEIN-KINASES AND HISTIDYL-TRANSFER RNA-SYNTHETASES IN GCN2 PROTEIN SUGGESTS A MECHANISM FOR COUPLING GCN4 EXPRESSION TO AMINO-ACID AVAILABILITY [J].

WEK, RC ;

JACKSON, BM ;

HINNEBUSCH, AG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) :4579-4583

[37] MUTATIONS IN THE STRUCTURAL GENES FOR EUKARYOTIC INITIATION-FACTORS 2-ALPHA AND 2-BETA OF SACCHAROMYCES-CEREVISIAE DISRUPT TRANSLATIONAL CONTROL OF GCN4 MESSENGER-RNA [J].

WILLIAMS, NP ;

HINNEBUSCH, AG ;

DONAHUE, TF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (19) :7515-7519

[38]

YANG JM, 1992, J BIOL CHEM, V267, P20519

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