SIMULTANEOUS DETERMINATION OF 7-AMINOCEPHALOSPORANIC ACID AND 7-AMINODESACETOXYCEPHALOSPORANIC ACID BY 2ND DERIVATIVE SPECTROPHOTOMETRY

被引：13

作者：

MURILLO, JA

LEMUS, JM

GARCIA, LF

机构：

[1] Departamento de Quimica Analitica y Tegnologia de Alimentos, Universidad de Castilla, La Mancha CIUDAD REAL ESPAÑA

来源：

ANALYTICAL LETTERS | 1991年 / 24卷 / 04期

关键词：

7-AMINOCEPHALOSPORANIC ACID; 7-AMINODESACETOXY-CEPHALOSPORANIC ACID; BETA-LACTAMIC ANTIBIOTIC; 2ND DERIVATIVE SPECTROPHOTOMETRY; SIMULTANEOUS DETERMINATION;

D O I：

10.1080/00032719108052935

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A spectrophotometric method has been developed for the simultaneous determination of 7-aminocephalosporanic acid (7-ACA) and 7-aminodesacetoxycephalosporanic acid (7-ADCA) in mixtures via the second-derivative spectra, using the zero-crossing measurements. The procedure does not require any separation step. Calibration graphs are linear between 4.0-32.0-mu-g ml-1 of 7-ACA at 276.25 nm and between 4.0-32.0-mu-g ml-1 of 7-ADCA at 278.50 nm, in the presence of each other.

引用

页码：683 / 699

页数：17

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