DETECTION OF THIOETHERS OF PHARMACEUTICAL IMPORTANCE BY LIQUID-CHROMATOGRAPHY WITH ONLINE GENERATED BROMINE

被引：39

作者：

KOK, WT ^{[1
]}

HALVAX, JJ ^{[1
]}

VOOGT, WH ^{[1
]}

BRINKMAN, UAT ^{[1
]}

FREI, RW ^{[1
]}

机构：

[1] FREE UNIV AMSTERDAM,DEPT ANALYT CHEM,DEBOELELAAN 1083,1081 HV AMSTERDAM,NETHERLANDS

来源：

ANALYTICAL CHEMISTRY | 1985年 / 57卷 / 13期

关键词：

BROMINE;

D O I：

10.1021/ac00290a034

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new method is presented for the detection of thioethers after separation by high-performance liquid chromatography (HPLC). The method is based on the postcolumn oxidation of the thioethers by bromine, which is generated electrochemically in the column effluent. Detection is performed by amperometric measurement of the excess of bromine downstream, after reaction with eluting thioethers. For the determination of ampicillin in plasma and urine a superior sensitivity and selectivity compared to the usual UV detection is shown.

引用

页码：2580 / 2583

页数：4

共 27 条

[1]

Albery W. J., 1971, RING DISC ELECTRODES

[2]

BARRETT GC, 1979, COMPREHENSIVE ORGANI, V3, P33

[3]

Block E., 1980, CHEM FUNCTIONAL 1 SE, P539

[4]

BOUTAGY J, 1984, J LIQ CHROMATOGR, V7, P1651, DOI 10.1080/01483918408074073

[5] DETERMINATION OF AMOXICILLIN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH AMPEROMETRIC DETECTION [J].

BROOKS, MA ;

HACKMAN, MR ;

MAZZO, DJ .

JOURNAL OF CHROMATOGRAPHY, 1981, 210 (03) :531-535

[6] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF RANITIDINE IN PLASMA [J].

CAREY, PF ;

MARTIN, LE .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1979, 2 (09) :1291-1303

[7] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHODS FOR THE DETERMINATION OF RANITIDINE AND ITS METABOLITES IN BIOLOGICAL-FLUIDS [J].

CAREY, PF ;

MARTIN, LE ;

EVANS, MB .

CHROMATOGRAPHIA, 1984, 19 :200-205

[8] DETERMINATION OF AMOXICILLIN IN BODY-FLUIDS BY REVERSED-PHASE LIQUID-CHROMATOGRAPHY COUPLED WITH A POST-COLUMN DERIVATIZATION PROCEDURE [J].

CARLQVIST, J ;

WESTERLUND, D .

JOURNAL OF CHROMATOGRAPHY, 1979, 164 (03) :373-381

[9] QUANTITATIVE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CEFATRIZINE IN SERUM AND URINE BY FLUORESCENCE DETECTION AFTER POST-COLUMN DERIVATIZATION [J].

CROMBEZ, E ;

VANDERWEKEN, G ;

VANDENBOSSCHE, W ;

DEMOERLOOSE, P .

JOURNAL OF CHROMATOGRAPHY, 1979, 177 (02) :323-332

[10] DESIGN AND SELECTIVE APPLICATION OF A DROPPING MERCURY-ELECTRODE AMPEROMETRIC DETECTOR IN COLUMN LIQUID-CHROMATOGRAPHY [J].

HANEKAMP, HB ;

BOS, P ;

FREI, RW .

JOURNAL OF CHROMATOGRAPHY, 1979, 186 (DEC) :489-496

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