PRO-CARBOXYPEPTIDASE-R CLEAVES BRADYKININ FOLLOWING ACTIVATION

被引：61

作者：

SHINOHARA, T

SAKURADA, C

SUZUKI, T

TAKEUCHI, O

CAMPBELL, W

IKEDA, S

OKADA, N

OKADA, H

机构：

[1] FUKUOKA UNIV,SCH MED,DEPT MICROBIOL,JOHNAN KU,FUKUOKA 81401,JAPAN

[2] FUKUOKA UNIV,SCH MED,DEPT SURG 1,FUKUOKA,JAPAN

[3] NAGOYA CITY UNIV,SCH MED,DEPT MOLEC BIOL,NAGOYA,AICHI,JAPAN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 103卷 / 04期

关键词：

CARBOXYPEPTIDASE R; TRYPSIN-ACTIVATED CARBOXYPEPTIDASE; BRADYKININ;

D O I：

10.1159/000236661

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Arginine carboxypeptidase (CPR) is a labile enzyme present in human serum which is unrelated to carboxypeptidase N. In this study we demonstrate that CPR exists in a precursor form in plasma and can be converted to the active form by trypsin and presumable trypsin-like enzymes. The trypsin-generated active form can not only cleave a small synthetic substrate, hippuryl-L-arginine, but can remove terminal arginine from bradykinin.

引用

页码：400 / 404

页数：5