THE DOLASTATINS .21. SYNTHESIS, X-RAY CRYSTAL-STRUCTURE, AND MOLECULAR MODELING OF (6R)-ISODOLASTATIN-10

被引：16

作者：

PETTIT, GR ^{[1
]}

SRIRANGAM, JK ^{[1
]}

HERALD, DL ^{[1
]}

HAMEL, E ^{[1
]}

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 21期

关键词：

D O I：

10.1021/jo00100a001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical synthesis of (GR)-isodolastatin 10 (1b) was devised, the X-ray crystal structure was determined, and this chiral isomer was found to have antineoplastic activity comparable to dolastatin 10 (1a).

引用

页码：6127 / 6130

页数：4