BARCELONEIC ACID-A, A NEW FARNESYL-PROTEIN TRANSFERASE INHIBITOR FROM A PHOMA SPECIES

被引：47

作者：

JAYASURIYA, H ^{[1
]}

BALL, RG ^{[1
]}

ZINK, DL ^{[1
]}

SMITH, JL ^{[1
]}

GOETZ, MA ^{[1
]}

JENKINS, RG ^{[1
]}

NALLINOMSTEAD, M ^{[1
]}

SILVERMAN, KC ^{[1
]}

BILLS, GF ^{[1
]}

LINGHAM, RB ^{[1
]}

SINGH, SB ^{[1
]}

PELAEZ, F ^{[1
]}

CASCALES, C ^{[1
]}

机构：

[1] MERCK SHARP & DOHME ESPANA SA,CTR INVEST BASICA,E-28027 MADRID,SPAIN

来源：

JOURNAL OF NATURAL PRODUCTS-LLOYDIA | 1995年 / 58卷 / 07期

关键词：

D O I：

10.1021/np50121a002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new diphenyl ethers, barceloneic acids A, B, and barceloneic lactone [1, 2, and 3, respectively] were isolated from a fermentation extract of a fungus of the genus Phoma. The structures of compounds 1-3 were determined by a combination of spectroscopic and single-crystal X-ray diffraction methods. The effect of these compounds on the inhibition of farnesyl-protein transferase (FPTase) was evaluated and results are presented. Barceloneic acid A [1] is a novel and modest inhibitor of FPTase with an IC50 value of 40 mu M.

引用

页码：986 / 991

页数：6

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