RESISTANCE TO AMPHOTERICIN-B ASSOCIATED WITH DEFECTIVE STEROL DELTA(8-]7) ISOMERASE IN A CRYPTOCOCCUS-NEOFORMANS STRAIN FROM AN AIDS PATIENT

被引：96

作者：

KELLY, SL

LAMB, DC

TAYLOR, M

CORRAN, AJ

BALDWIN, BC

POWDERLY, WG

机构：

[1] ZENECA AGROCHEM,JEALOTTS HILL RES STN,BRACKNELL RG12 6EY,BERKS,ENGLAND

[2] WASHINGTON UNIV,SCH MED,ST LOUIS,MO 63110

来源：

FEMS MICROBIOLOGY LETTERS | 1994年 / 122卷 / 1-2期

基金：

英国惠康基金;

关键词：

RESISTANCE; AMPHOTERICIN B; CRYPTOCOCCUS NEOFORMANS;

D O I：

10.1111/j.1574-6968.1994.tb07140.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The sterol composition of CN3 indicated a defect in sterol Delta(8-->7) isomerase in this strain and depletion of ergosterol, the major sterol of the CN1.

引用

页码：39 / 42

页数：4

共 6 条

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