THE CEPH CONSORTIUM LINKAGE MAP OF HUMAN CHROMOSOME-15Q

被引：15

作者：

BOWCOCK, AM

BARNES, RI

WHITE, RL

KRUSE, TA

TSIPOURAS, P

SARFARAZI, M

JENKINS, T

VILJOEN, C

LITT, M

KRAMER, PL

MURRAY, JC

VERGNAUD, G

机构：

[1] UNIV UTAH,MED CTR,HOWARD HUGHES MED INST,SALT LAKE CITY,UT 84132

[2] UNIV UTAH,MED CTR,DEPT HUMAN GENET,SALT LAKE CITY,UT 84132

[3] AARHUS UNIV,INST HUMAN GENET,DK-8000 AARHUS,DENMARK

[4] UNIV CONNECTICUT,CTR HLTH,DEPT PEDIAT,FARMINGTON,CT 06030

[5] S AFRICAN INST MED RES,SCH PATHOL,DEPT HUMAN GENET,MRC,HUMAN ECOGENET RES UNIT,JOHANNESBURG 2000,SOUTH AFRICA

[6] UNIV WITWATERSRAND,JOHANNESBURG 2001,SOUTH AFRICA

[7] OREGON HLTH SCI UNIV,DEPT NEUROL BIOCHEM,PORTLAND,OR 97201

[8] UNIV IOWA,DEPT PEDIAT,IOWA CITY,IA 52242

[9] CTR ETUD BOUCHET,F-91710 VERT LE PETIT,FRANCE

来源：

GENOMICS | 1992年 / 14卷 / 04期

关键词：

D O I：

10.1016/S0888-7543(05)80101-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The CEPH consortium map of chromosome 15q is presented. The map contains 41 loci defined by genotypes generated from CEPH family DNAs with 45 different probe and restriction enzyme combinations contributed by 10 laboratories. A total of 29 loci have been placed on the map with likelihood support of at least 1000:1. The map extends from 15q13 to 15q25-qter. Multipoint linkage analyses provided estimates that the male, female, and sex-averaged maps extend for 127, 190, and 158 cM, respectively. The largest interval is 21 cM and is between D15S37 and D15S74. The on-average locus spacing is 5.6 cM and the mean genetic distance between the 21 uniquely placed loci is 8 cM. © 1992 Academic Press, Inc. All rights reserved.

引用

页码：833 / 840

页数：8

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[41] A NEW MARKER ON CHROMOSOME-15, D15S74, DETECTS 3 RFLPS [J].