AN EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF INDICINE N-OXIDE, AN ANTITUMOR PYRROLIZIDINE ALKALOID

被引：18

作者：

OGAWA, T ^{[1
]}

NIWA, H ^{[1
]}

YAMADA, K ^{[1
]}

机构：

[1] NAGOYA UNIV,FAC SCI,DEPT CHEM,NAGOYA,AICHI 464,JAPAN

来源：

TETRAHEDRON | 1993年 / 49卷 / 08期

关键词：

D O I：

10.1016/S0040-4020(01)80345-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Indicine N-oxide (1), a pyrrolizidine alkaloid potentially useful for an anticancer drug was synthesized in the natural form through regioselective coupling of (+)-retronecine (2) and the protected necic acids 16a and 16b, the latter being efficiently prepared from the optically pure lactone 5.

引用

页码：1571 / 1578

页数：8

共 27 条

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[9] AN EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF THE (-)-N-(ETHOXYCARBONYL)METHYL GEISSMAN-WAISS LACTONE - A PRACTICAL SYNTHETIC ROUTE TO (+)-RETRONECINE
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