Homologues of Arabidopsis Microtubule-Associated AIR9 in Trypanosomatid Parasites Hints on Evolution and Function

被引：8

作者：

Buschmann, Henrik ^{[1
]}

Sanchez-Pulido, Luis ^{[2
]}

Andrade-Navarro, Miguel A. ^{[3
]}

Lloyd, Clive W. ^{[1
]}

机构：

[1] John Innes Ctr, Dept Cell & Dev Biol, Norwich, Norfolk, England

[2] Ctr Nacl Biotecnol, Madrid, Spain

[3] Ottawa Hlth Res Inst, Mol Med, Ottawa, ON, Canada

来源：

PLANT SIGNALING & BEHAVIOR | 2007年 / 2卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

plant; cortical microtubules; preprophase band; A9; domain; flagellum; Excavata;

D O I：

10.4161/psb.2.4.4041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

AIR9 is an essential microtubule-associated protein from Arabidopsis. Sequence similarity searches indicate homologues of AIR9 in land plants and in excavate protists, including trypanosomatid parasites and Trichomonas. The AIR9-like protein from Trypanosoma brucei was recently detected in the proteome of the trypanosome flagellum, raising the possibility that trypanosomatid AIR9-like proteins also associate with microtubules. Because microtubule functions are essential to the viability of trypanosomatid parasites AIR9-like proteins may be exploited as drug targets without homology in humans. We further discuss the unexpected phylogeny of AIR9-like proteins from plants and protozoans.

引用

页码：296 / 299

页数：4

共 17 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[2] Flagellar motility is required for the viability of the bloodstream trypanosome [J].

Broadhead, R ;

Dawe, HR ;

Farr, H ;

Griffiths, S ;

Hart, SR ;

Portman, N ;

Shaw, MK ;

Ginger, ML ;

Gaskell, SJ ;

McKean, PG ;

Gull, K .

NATURE, 2006, 440 (7081) :224-227

[3] Monophyly of Rhizaria and multigene phylogeny of unicellular bikonts [J].

Burki, Fabien ;

Pawlowski, Jan .

MOLECULAR BIOLOGY AND EVOLUTION, 2006, 23 (10) :1922-1930

[4] Microtubule-associated AIR9 recognizes the cortical division site at preprophase and cell-plate insertion [J].

Buschmann, Henrik ;

Chan, Jordi ;

Sanchez-Pulido, Luis ;

Andrade-Navarro, Miguel A. ;

Doonan, John H. ;

Lloyd, Clive W. .

CURRENT BIOLOGY, 2006, 16 (19) :1938-1943

[5] Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis [J].

Carlton, Jane M. ;

Hirt, Robert P. ;

Silva, Joana C. ;

Delcher, Arthur L. ;

Schatz, Michael ;

Zhao, Qi ;

Wortman, Jennifer R. ;

Bidwell, Shelby L. ;

Alsmark, U. Cecilia M. ;

Besteiro, Sebastien ;

Sicheritz-Ponten, Thomas ;

Noel, Christophe J. ;

Dacks, Joel B. ;

Foster, Peter G. ;

Simillion, Cedric ;

Van de Peer, Yves ;

Miranda-Saavedra, Diego ;

Barton, Geoffrey J. ;

Westrop, Gareth D. ;

Mueller, Sylke ;

Dessi, Daniele ;

Fiori, Pier Luigi ;

Ren, Qinghu ;

Paulsen, Ian ;

Zhang, Hanbang ;

Bastida-Corcuera, Felix D. ;

Simoes-Barbosa, Augusto ;

Brown, Mark T. ;

Hayes, Richard D. ;

Mukherjee, Mandira ;

Okumura, Cheryl Y. ;

Schneider, Rachel ;

Smith, Alias J. ;

Vanacova, Stepanka ;

Villalvazo, Maria ;

Haas, Brian J. ;

Pertea, Mihaela ;

Feldblyum, Tamara V. ;

Utterback, Terry R. ;

Shu, Chung-Li ;

Osoegawa, Kazutoyo ;

de Jong, Pieter J. ;

Hrdy, Ivan ;

Horvathova, Lenka ;

Zubacova, Zuzana ;

Dolezal, Pavel ;

Malik, Shehre-Banoo ;

Logsdon, John M., Jr. ;

Henze, Katrin ;

Gupta, Arti .

SCIENCE, 2007, 315 (5809) :207-212

[6] Comparative genomics of trypanosomatid parasitic protozoa [J].

El-Sayed, NM ;

Myler, PJ ;

Blandin, G ;

Berriman, M ;

Crabtree, J ;

Aggarwal, G ;

Caler, E ;

Renauld, H ;

Worthey, EA ;

Hertz-Fowler, C ;

Ghedin, E ;

Peacock, C ;

Bartholomeu, DC ;

Haas, BJ ;

Tran, AN ;

Wortman, JR ;

Alsmark, UCM ;

Angiuoli, S ;

Anupama, A ;

Badger, J ;

Bringaud, F ;

Cadag, E ;

Carlton, JM ;

Cerqueira, GC ;

Creasy, T ;

Delcher, AL ;

Djikeng, A ;

Embley, TM ;

Hauser, C ;

Ivens, AC ;

Kummerfeld, SK ;

Pereira-Leal, JB ;

Nilsson, D ;

Peterson, J ;

Salzberg, SL ;

Shallom, J ;

Silva, JC ;

Sundaram, J ;

Westenberger, S ;

White, O ;

Metville, SE ;

Donelson, JE ;

Andersson, B ;

Stuart, KD ;

Hall, N .

SCIENCE, 2005, 309 (5733) :404-409

[7] Eukaryotic evolution, changes and challenges [J].

Embley, TM ;

Martin, W .

NATURE, 2006, 440 (7084) :623-630

[8] Plant-like traits associated with metabolism of Trypanosoma parasites [J].

Hannaert, V ;

Saavedra, E ;

Duffieux, F ;

Szikora, JP ;

Rigden, DJ ;

Michels, PAM ;

Opperdoes, FR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) :1067-1071

[9] Diversity and evolutionary history of plastids and their hosts [J].

Keeling, PJ .

AMERICAN JOURNAL OF BOTANY, 2004, 91 (10) :1481-1493

[10] Purification and cloning of chloroplast 6-phosphogluconate dehydrogenase from spinach - Cyanobacterial genes for chloroplast and cytosolic isoenzymes encoded in eukaryotic chromosomes [J].

Krepinsky, K ;

Plaumann, M ;

Martin, W ;

Schnarrenberger, C .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2001, 268 (09) :2678-2686

← 1 2 →