SINGLE-DOSE PHARMACOKINETICS OF CARBAMAZEPINE-10,11-EPOXIDE IN PATIENTS ON LAMOTRIGINE MONOTHERAPY

被引：22

作者：

PISANI, F

XIAO, B

FAZIO, A

SPINA, E

PERUCCA, E

TOMSON, T

机构：

[1] UNIV MESSINA,HOSP PSYCHIAT,I-98013 MESSINA,ITALY

[2] UNIV MESSINA,INST PHARMACOL,I-98013 MESSINA,ITALY

[3] UNIV PAVIA,DEPT MED PHARMACOL,I-27100 PAVIA,ITALY

[4] KAROLINSKA HOSP,DEPT NEUROL,S-10401 STOCKHOLM,SWEDEN

来源：

EPILEPSY RESEARCH | 1994年 / 19卷 / 03期

关键词：

CARBAMAZEPINE-10,11-EPOXIDE; LAMOTRIGINE; DRUG INTERACTION;

D O I：

10.1016/0920-1211(94)90068-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The pharmacokinetics of a single oral dose of carbamazepine-10,11-epoxide (CBZ-E, 100 mg) were compared in 10 patients on chronic monotherapy with lamotrigine (LTG, 200-300 mg/day) and in 10 drug-free healthy control subjects. CBZ-E pharmacokinetic parameters in LTG-treated patients were found to be similar to those observed in controls (half-life: 7.2 +/- 1.6 vs 6.1 +/- 0.9 h; apparent oral clearance: 110.8 +/- 53.1 vs 120.5 +/- 29.9 ml/h/kg; apparent volume of distribution: 1.08 +/- 0.37 vs 1.04 +/- 0.25 l/kg respectively; means +/- s.d.). These data indicate that, contrary to previous suggestions, LTG has no effect on the metabolic disposition of CBZ-E.

引用

页码：245 / 248

页数：4

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