N-(BOC)-L-(2-BROMOALLYL)-GLYCINE - A VERSATILE INTERMEDIATE FOR THE SYNTHESIS OF OPTICALLY-ACTIVE UNNATURAL AMINO-ACIDS

被引：41

作者：

LEANNA, MR

MORTON, HE

机构：

[1] Process Chemistry, Department 4.5L, APIO, Abbott Park

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 28期

关键词：

D O I：

10.1016/0040-4039(93)88065-Q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N(Boc)-L-(2-Bromoallyl)-glycine (1) was synthesized from diethylacetamidomalonate and 2,3-dibromopropene in a one-pot procedure (75% overall yield). The enantiomers were efficiently separated via a tandem biocatalytic kinetic hydrolytic resolution. 1 was elaborated to several other interesting unnatural amino acids.

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页码：4485 / 4488

页数：4

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