DUAL INHIBITION OF NEUTRAL ENDOPEPTIDASE AND ANGIOTENSIN-CONVERTING ENZYME BY N-PHOSPHONOMETHYL AND N-CARBOXYALKYL DIPEPTIDES

被引：13

作者：

DELOMBAERT, S

TAN, J

STAMFORD, LJ

SAKANE, Y

BERRY, C

GHAI, RD

机构：

[1] Research Department, Pharmaceutical Division, CIBA-GEIGY Corporation, Summit

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(01)80703-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structural modifications have been performed on the selective a-amino phosphonic acid NEP inhibitor CGS 24592, to achieve dual ACE/NEP inhibition in vitro. (S)-N-Phosphonomethyl-valyl-(S)-(4-phenyl)phenylalanine (19) is representative of a new type of phosphorus-containing ACE/NEP inhibitors, approaching the in vitro potency of the sulfhydryl ACE inhibitor captopril and the NEP inhibitor thiorphan.

引用

页码：2715 / 2720

页数：6

共 30 条

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