THE TRK PROTOONCOGENE PRODUCT - A SIGNAL TRANSDUCING RECEPTOR FOR NERVE GROWTH-FACTOR

被引：1273

作者：

KAPLAN, DR

HEMPSTEAD, BL

MARTINZANCA, D

CHAO, MV

PARADA, LF

机构：

[1] NCI,FREDERICK CANC RES & DEV CTR,BASIC RES PROGRAM,ADV BIOSCI LAB,FREDERICK,MD 21701

[2] CORNELL UNIV,MED CTR,COLL MED,DEPT CELL BIOL & ANAT,NEW YORK,NY 10021

[3] CORNELL UNIV,MED CTR,COLL MED,DEPT MED,DIV HEMATOL ONCOL,NEW YORK,NY 10021

来源：

SCIENCE | 1991年 / 252卷 / 5005期

关键词：

D O I：

10.1126/science.1850549

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The trk proto-oncogene encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase (p140prototrk) that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of p140prototrk in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with I-125-labeled NGF indicate that p140prototrk binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of p140prototrk as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF.

引用

页码：554 / 558

页数：5

共 56 条

[11] EMBRYOLOGIC DEVELOPMENT OF A MOUSE SYMPATHETIC-GANGLION INVIVO AND INVITRO
COUGHLIN, MD
BOYER, DM
BLACK, IB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (08) : 3438 - 3442
[12] NERVE GROWTH-FACTOR RECEPTORS ON HUMAN MELANOMA CELLS IN CULTURE
FABRICANT, RN
DELARCO, JE
TODARO, GJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (02) : 565 - 569
[13] GREEN SH, 1986, J BIOL CHEM, V261, P5316
[14] ESTABLISHMENT OF A NORADRENERGIC CLONAL LINE OF RAT ADRENAL PHEOCHROMOCYTOMA CELLS WHICH RESPOND TO NERVE GROWTH-FACTOR
GREENE, LA
TISCHLER, AS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (07) : 2424 - 2428
[15] NEURONAL DEATH IN THE SPINAL GANGLIA OF THE CHICK-EMBRYO AND ITS REDUCTION BY NERVE GROWTH-FACTOR
HAMBURGER, V
BRUNSOBECHTOLD, JK
YIP, JW
[J]. JOURNAL OF NEUROSCIENCE, 1981, 1 (01) : 60 - 71
[16] PROLIFERATION, DIFFERENTIATION AND DEGENERATION IN THE SPINAL GANGLIA OF THE CHICK EMBRYO UNDER NORMAL AND EXPERIMENTAL CONDITIONS
HAMBURGER, V
LEVIMONTALCINI, R
[J]. JOURNAL OF EXPERIMENTAL ZOOLOGY, 1949, 111 (03): : 457 - 501
[17] THE PROTEIN-KINASE FAMILY - CONSERVED FEATURES AND DEDUCED PHYLOGENY OF THE CATALYTIC DOMAINS
HANKS, SK
QUINN, AM
HUNTER, T
[J]. SCIENCE, 1988, 241 (4861) : 42 - 52
[18] EXPRESSION OF FUNCTIONAL NERVE GROWTH-FACTOR RECEPTORS AFTER GENE-TRANSFER
HEMPSTEAD, BL
SCHLEIFER, LS
CHAO, MV
[J]. SCIENCE, 1989, 243 (4889) : 373 - 375
[19] HEMPSTEAD BL, 1990, J BIOL CHEM, V265, P9595
[20] HEMPSTEAD BL, UNPUB

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