DEGENERATIVE AND REGENERATIVE RESPONSES OF INJURED NEURONS IN THE CENTRAL-NERVOUS-SYSTEM OF ADULT MAMMALS

被引：175

作者：

AGUAYO, AJ ^{[1
]}

RASMINSKY, M ^{[1
]}

BRAY, GM ^{[1
]}

CARBONETTO, S ^{[1
]}

MCKERRACHER, L ^{[1
]}

VILLEGASPEREZ, MP ^{[1
]}

VIDALSANZ, M ^{[1
]}

CARTER, DA ^{[1
]}

机构：

[1] MONTREAL GEN HOSP, MONTREAL H3G 1A4, QUEBEC, CANADA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 1991年 / 331卷 / 1261期

关键词：

D O I：

10.1098/rstb.1991.0025

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In adult mammals, the severing of the optic nerve near the eye is followed by a loss of retinal ganglion cells (RGCs) and a failure of axons to regrow into the brain. Experimental manipulations of the non-neuronal environment of injured RGCs enhance neuronal survival and make possible a lengthy axonal regeneration that restores functional connections with the superior colliculus. These effects suggest that injured nerve cells in the mature central nervous system (CNS) are strongly influenced by interactions with components of their immediate environment as well as their targets. Under these conditions, injured CNS neurons can express capacities for growth and differentiation that resemble those of normally developing neurons. An understanding of this regeneration in the context of the cellular and molecular events that influence the interactions of axonal growth cones with their non-neuronal substrates and neuronal targets should help in the further elucidation of the capacities of neuronal systems to recover from injury.

引用

页码：337 / 343

页数：7

共 52 条

[21] ELECTROPHYSIOLOGIC RESPONSES IN HAMSTER SUPERIOR COLLICULUS EVOKED BY REGENERATING RETINAL AXONS [J].