BETA-LACTAMASE PRODUCTION AND SUSCEPTIBILITY OF UNITED-STATES AND EUROPEAN ANAEROBIC GRAM-NEGATIVE BACILLI TO BETA-LACTAMS AND OTHER AGENTS

被引:27
作者
JACOBS, MR
SPANGLER, SK
APPELBAUM, PC
机构
[1] UNIV HOSP CLEVELAND,CLEVELAND,OH 44106
[2] PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT PATHOL,HERSHEY,PA 17033
关键词
D O I
10.1007/BF01967803
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The susceptibility of 1,476 US and European strains of anaerobic gram-negative bacilli to amoxicillin, amoxicillin/clavulanate, ticarcillin, ticarcillin/clavulanate, cefoxitin, imipenem and metronidazole was determined. All of the Bacteroides fragilis group and 51 % of the non-Bacteroides fragilis group were beta-lactamase positive. Amongst the non-Bacteroides fragilis group, beta-lactamase positivity rates were higher for US strains (58 %) than for European strains (39 %). All strains were susceptible to imipenem and metronidazole. MIC90s of amoxicillin and ticarcillin for all beta-lactamase negative strains were 0.5 and 2 mug/ml, respectively. The addition of clavulanate reduced the MIC90s of amoxicillin (greater-than-or-equal-to 256 pg/ml) and ticarcillin (greater-than-or-equal-to 64 mug/ml) to 16 and 8 mug/ml, respectively, for the Bacteroides fragilis group, and to 4 mug/ml for both agents for the non-Bacteroides fragilis beta-lactamase producing group. Twenty-nine cefoxitin-resistant strains were found, mainly in the Bacteroides fragilis group, while 95 beta-lactamase producing strains (predominantly Bacteroides fragilis group and fusobacteria) did not show synergy between beta-lactams and clavulanate. Of the newer agents tested, meropenem and piperacillin-tazobactam were the most active (100 % of strains susceptible), followed by amoxicillin-BRL 42715 (99 % of strains susceptible); 94 to 98 % of the strains were susceptible to cefoperazone-sulbactam, tosufloxacin, temafloxacin and clindamycin. Only 73 % of the strains were susceptible to cefotetan, compared to 91 % to cefoxitin; 88 % of the strains were susceptible to trospectomycin. Overall, all of the beta-lactam/beta-lactamase inhibitor combinations, imipenem, meropenem, cefoxitin, tosufloxacin, temafloxacin and clindamycin had good activity against beta-lactamase producing strains, while all agents tested had good activity against beta-lactamase negative strains.
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页码:1081 / 1093
页数:13
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