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[21]
ZINKERNAGEL RM, 1990, CURR TOP MICROBIOL, V159, P65
CYTOTOXIC T-CELL MEMORY WITHOUT ANTIGEN
被引：584
作者：
LAU, LL
[1
]
JAMIESON, BD
[1
]
SOMASUNDARAM, T
[1
]
AHMED, R
[1
]
机构：
[1] UNIV CALIF LOS ANGELES, SCH MED, DEPT MICROBIOL & IMMUNOL, LOS ANGELES, CA 90024 USA
来源：
关键词：
D O I：
10.1038/369648a0
中图分类号：
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号：
07 ;
0710 ;
09 ;
摘要：
Memory is a hallmark of the immune system and ever since its recognition there has been considerable interest in understanding how immunity is maintained(1-5). The current model is that long-term memory is dependent on persistent antigenic stimulation(6-11). We report here results that challenge this view and provide evidence that antigen is not essential for the maintenance of CD8(+) T-cell memory. We show that memory CD8(+) cytotoxic T lymphocytes persist indefinitely in the absence of priming antigen, retain the memory phenotype (CD44(hi)), and provide protection against virus challenge. These findings suggest a re-evaluation of our current thinking on mechanisms involved in maintaining immunity and have implications towards designing effective vaccination strategies.
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页码：648 / 652
页数：5
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