INVESTIGATION OF STRUCTURE-PROPERTY RELATIONSHIPS FOR IMIDAZOQUINOLONE DERIVATIVES .1. RELATION BETWEEN PARTITION-COEFFICIENT AND CHROMATOGRAPHIC RETENTION

New imidazoquinazolone derivatives as potential pharmacons, prepared in our laboratory, have been studied by HPLC and TLC methods. As a part of a structure-properties research study (SPR) this paper deals with the relationship between the chemical structure of the compounds and their chromatographic retention. A good correlation has been found between log k’ or RM and the concentration of the organic modifier in mobile phase, as well as log k’ or rmand log P. On the basis of the measured retention data, log P prediction was made for compounds with very poor watersolubility. © 1990, Taylor & Francis Group, LLC. All rights reserved.