APPLICATION OF SUPERCRITICAL FLUIDS FOR THE PRODUCTION OF SUSTAINED DELIVERY DEVICES

被引：117

作者：

DEBENEDETTI, PG

TOM, JW

YEO, SD

LIM, GB

机构：

[1] Department of Chemical Engineering, Princeton University, Princeton

来源：

JOURNAL OF CONTROLLED RELEASE | 1993年 / 24卷 / 1-3期

关键词：

SUPERCRITICAL FLUID; SUSTAINED DELIVERY DEVICE; RAPID EXPANSION; ANTI-SOLVENT PRECIPITATION;

D O I：

10.1016/0168-3659(93)90166-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Supercritical fluids are attractive as vehicles for the formation of particles of biomedical interest. We review two novel techniques: the rapid expansion of supercritical solutions for the formation of solvent-free, drug-loaded, injectable microspheres, and the gas anti-solvent precipitation process for the formation of ultrafine and biologically active protein powders.

引用

页码：27 / 44

页数：18

共 36 条

[31] FORMATION OF BIOERODIBLE POLYMERIC MICROSPHERES AND MICROPARTICLES BY RAPID EXPANSION OF SUPERCRITICAL SOLUTIONS [J].