THE CELLULAR AND PHYSIOLOGICAL ACTIONS OF INSULIN IN THE CENTRAL-NERVOUS-SYSTEM

被引:188
作者
WOZNIAK, M
RYDZEWSKI, B
BAKER, SP
RAIZADA, MK
机构
[1] UNIV FLORIDA,COLL MED,DEPT PHYSIOL,GAINESVILLE,FL 32610
[2] UNIV FLORIDA,COLL MED,DEPT PHARMACOL & THERAPEUT,GAINESVILLE,FL 32610
关键词
D O I
10.1016/0197-0186(93)90062-A
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Insulin is a peptide hormone involved in the regulation of glucose homeostasis. Its synthesis and function in the peripheral tissues have been extensively studied and well understood. In contrast, demonstration of insulin in the brain has raised questions concerning its origin and physiological significance. In spite of extensive studies, the source of insulin present in the brain has not yet been conclusively identified. Evidence exists in support of both peripheral and central origins of this hormone in the brain. Recognized physiological effects of insulin in the central nervous system (CNS) include regulation of food intake, control of glucose uptake and trophic actions on neuronal and glial cells. These actions of insulin are mediated by insulin receptor resembling closely that in peripheral tissues and coupled with tyrosine kinase signal transduction pathway. In this review we will discuss theories concerning the origin of insulin in the CNS. In addition, we will present current information on both cellular and physiological effects of this hormone in the brain.
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页码:1 / 10
页数:10
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